STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lipTRv2045c, (MTV018.32c), len: 511 aa. LipT,carboxylesterase, similar to many. Contains PS00941 Carboxylesterases type-B signature 2. Contains PS00122 Carboxylesterases type-B serine active site; Belongs to the type-B carboxylesterase/lipase family. (511 aa)    
Predicted Functional Partners:
Rv0948c
Probable mycolyl transferase, pseudogene; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
  
  
 0.810
Rv2044c
Rv2044c, (MTV018.31c), len: 105 aa. Conserved hypothetical protein, similar to many.
  
    0.785
mrp
Probable Mrp-related protein Mrp; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; In the C-terminal section; belongs to the Mrp/NBP35 ATP- binding proteins family.
   
  
 0.753
gmk
Probable guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP.
   
 0.745
Rv2681
Rv2681, (MTCY05A6.02), len: 438 aa. Conserved hypothetical ala-rich protein, equivalent to Q50004|ML1040|U1764U hypothetical protein from Mycobacterium leprae (429 aa), FASTA scores: opt: 2146,E(): 1.1e-119, (77.4% identity in 416 aa overlap). Also highly similar to O69858|SC1C3.16c hypothetical 42.5 KDA protein from Streptomyces coelicolor (394 aa), FASTA scores: opt: 1336, E(): 9e-72, (51.6% identity in 405 aa overlap); and with some similarity to ribonucleases D e.g. Q983F2|MLL8354 from Rhizobium loti (Mesorhizobium loti) (383 aa), FASTA scores: opt: 379, E(): 3.9e-15, (31.6% identi [...]
   
  0.732
Rv1770
Conserved protein; Rv1770, (MTCY28.36), len: 428 aa. Conserved protein,highly similar in N-terminus to Q49882 Hypothetical protein from Mycobacterium leprae from cosmid L247 (83 aa), FASTA scores: opt: 301, E(): 1e-12, (56.5% identity in 85 aa overlap).
  
 0.715
gcvT
Probable aminomethyltransferase GcvT (glycine cleavage system T protein); The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.
      
 0.714
lpqL
Probable lipoprotein aminopeptidase LpqL; An aminopeptidase; acts on free N-terminal amino groups with a very strong preference for Leu in the first position. Belongs to the peptidase M28 family. M28A subfamily.
  
 0.711
rpsD
30S ribosomal protein S4 RpsD; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. Belongs to the universal ribosomal protein uS4 family.
    
  0.700
rpsK
30S ribosomal protein S11 RpsK; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family.
    
  0.684
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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