node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobG | cobH | Rv2064 | Rv2065 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.998 |
cobG | cobI | Rv2064 | Rv2066 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.998 |
cobG | cobK | Rv2064 | Rv2070c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.910 |
cobG | cobL | Rv2064 | Rv2072c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.939 |
cobG | cobM | Rv2064 | Rv2071c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.822 |
cobG | cobN | Rv2064 | Rv2062c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.952 |
cobG | cysG | Rv2064 | Rv2847c | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Rv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-III c-methyltransferase, precorrin-2 oxidase and ferrochelatase. C-terminus highly similar to many uroporphyrin-III c-methyltransferases e.g. Q51720|COBA uroporphyrinogen III methyltransferase from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): [...] | 0.882 |
cobG | hemD | Rv2064 | Rv0511 | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | Uroporphyrinogen III methyltransferase / synthase; Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase, highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF [...] | 0.893 |
cobH | cobG | Rv2065 | Rv2064 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.998 |
cobH | cobI | Rv2065 | Rv2066 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.999 |
cobH | cobK | Rv2065 | Rv2070c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.986 |
cobH | cobL | Rv2065 | Rv2072c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.999 |
cobH | cobM | Rv2065 | Rv2071c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.979 |
cobH | cobN | Rv2065 | Rv2062c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.935 |
cobH | cobQ1 | Rv2065 | Rv0255c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.977 |
cobH | cobS | Rv2065 | Rv2208 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Probable cobalamin 5'-phosphate synthase CobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate (By similarity); Belongs to the CobS family. | 0.890 |
cobH | cysG | Rv2065 | Rv2847c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv2847c, (MTCY24A1.10), len: 405 aa. Possible cysG,multifunctional enzyme, siroheme synthase containing uroporphyrin-III c-methyltransferase, precorrin-2 oxidase and ferrochelatase. C-terminus highly similar to many uroporphyrin-III c-methyltransferases e.g. Q51720|COBA uroporphyrinogen III methyltransferase from Propionibacterium freudenreichii (257 aa), FASTA scores: opt: 776, E(): 1.5e-39, (48.95% identity in 243 aa overlap); Q9HMY4|UROM|VNG2331G S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase from Halobacterium sp. strain NRC-1 (246 aa), FASTA scores: opt: 704, E(): [...] | 0.679 |
cobH | hemD | Rv2065 | Rv0511 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Uroporphyrinogen III methyltransferase / synthase; Rv0511, (MTCY21C8.02), len: 565 aa. Probable hemD (alternate gene name: cysG), uroporphyrin-III C-methyltransferase, highly similar to others e.g. CAC31936.1|AL583925 possible uroporphyrin-III C-methyltransferase from Mycobacterium leprae (563 aa); and S72909|CYSG from Mycobacterium leprae (472 aa), FASTA scores: opt: 1946, E(): 0, (83.3% identity in 472 aa overlap); T36265|5123662|CAB45351.1|AL079345 probable uroporphyrin-III C-methyltransferase from Streptomyces coelicolor (565 aa); and similar to others e.g. AAK00606.1|AF221100_3|AF [...] | 0.541 |
cobI | cobG | Rv2066 | Rv2064 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Rv2064, (MTCY49.03), len: 363 aa. CobG, precorrin-3B synthase, cobalamin biosynthesis protein. | 0.998 |
cobI | cobH | Rv2066 | Rv2065 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.999 |