node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobH | cobI | Rv2065 | Rv2066 | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.999 |
cobH | cobK | Rv2065 | Rv2070c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.986 |
cobH | cobL | Rv2065 | Rv2072c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.999 |
cobH | cobM | Rv2065 | Rv2071c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.979 |
cobH | cobO | Rv2065 | Rv2849c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv2849c, (MTCY24A1.08), len: 207 aa. Probable cobO,cob(I)alamin adenosyltransferase, highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium [...] | 0.850 |
cobH | cobQ1 | Rv2065 | Rv0255c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.977 |
cobH | cobU | Rv2065 | Rv0254c | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | Rv0254c, (MTV034.20), len: 174 aa. Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase and cobinamide phosphate guanylyltransferase. Highly similar to many e.g. Q05599|COBU_SALTY cobinamide kinase / cobinamide phosphate guanylyltransferase from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14,(38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa), FASTA scor [...] | 0.881 |
cobI | cobH | Rv2066 | Rv2065 | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.999 |
cobI | cobK | Rv2066 | Rv2070c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | 0.999 |
cobI | cobL | Rv2066 | Rv2072c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.999 |
cobI | cobM | Rv2066 | Rv2071c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.999 |
cobI | cobO | Rv2066 | Rv2849c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Rv2849c, (MTCY24A1.08), len: 207 aa. Probable cobO,cob(I)alamin adenosyltransferase, highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium [...] | 0.866 |
cobI | cobQ1 | Rv2066 | Rv0255c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.999 |
cobI | cobU | Rv2066 | Rv0254c | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | Rv0254c, (MTV034.20), len: 174 aa. Probable cobU,cobalamin biosynthesis protein including a cobinamide kinase and cobinamide phosphate guanylyltransferase. Highly similar to many e.g. Q05599|COBU_SALTY cobinamide kinase / cobinamide phosphate guanylyltransferase from Salmonella typhimurium (181 aa), FASTA scores: opt: 308, E(): 1.1e-14,(38.7% identity in 181 aa overlap); P46886|COBU_ECOLI|B1993|Z3153|ECS2788 Bifunctional cobalamin biosynthesis protein cobU from Escherichia coli strains K12 and O157:H7 (181 aa); part of AL096872|SC5F7_10 from Streptomyces coelicolor (397 aa), FASTA scor [...] | 0.877 |
cobK | cobH | Rv2070c | Rv2065 | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Precorrin-8X methylmutase CobH (aka precorrin isomerase); Catalyzes the conversion of precorrin-8X to hydrogenobyrinate. | 0.986 |
cobK | cobI | Rv2070c | Rv2066 | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Cobalamin biosynthesis protein CobIJ; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. | 0.999 |
cobK | cobL | Rv2070c | Rv2072c | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Precorrin-6Y C(5,15)-methyltransferase (decarboxylating) CobL; Catalyzes the methylation of both C-5 and C-15 in precorrin- 6Y to form precorrin-8X. | 0.999 |
cobK | cobM | Rv2070c | Rv2071c | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Precorrin-3 methylase CobM (precorrin-4 C11-methyltransferase); Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5. | 0.998 |
cobK | cobO | Rv2070c | Rv2849c | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Rv2849c, (MTCY24A1.08), len: 207 aa. Probable cobO,cob(I)alamin adenosyltransferase, highly similar to Q9RJ17|COBO from Streptomyces coelicolor (199 aa), FASTA scores: opt: 918, E(): 1.1e-55, (64.75% identity in 207 aa overlap); and similar to others e.g. O30785|COBO from Rhodobacter capsulatus (Rhodopseudomonas capsulata) (212 aa), FASTA scores: opt: 329, E(): 2.8e-15, (44.3% identity in 185 aa overlap); P29930|COBO_PSEDE from Pseudomonas denitrificans (213 aa), FASTA scores: opt: 280, E(): 6.5e-12, (38.9% identity in 185 aa overlap); P31570|BTUR_SALTY|COBA from Salmonella typhimurium [...] | 0.906 |
cobK | cobQ1 | Rv2070c | Rv0255c | Precorrin-6X reductase CobK; Catalyzes the reduction of the macrocycle of precorrin-6X into precorrin-6Y. | Probable cobyric acid synthase CobQ1; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.912 |