node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2144c | sepF | Rv2144c | Rv2147c | Rv2144c, (MTCY270.24), len: 118 aa. Probable transmembrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. | 0.641 |
Rv2144c | wag31 | Rv2144c | Rv2145c | Rv2144c, (MTCY270.24), len: 118 aa. Probable transmembrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). | Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. | 0.952 |
cwsA | ftsQ | Rv0008c | Rv2151c | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | Possible cell division protein FtsQ; Essential cell division protein. | 0.670 |
cwsA | ftsZ | Rv0008c | Rv2150c | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.694 |
cwsA | pbpA | Rv0008c | Rv0016c | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.658 |
cwsA | pknA | Rv0008c | Rv0015c | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.406 |
cwsA | wag31 | Rv0008c | Rv2145c | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. | 0.980 |
ftsQ | cwsA | Rv2151c | Rv0008c | Possible cell division protein FtsQ; Essential cell division protein. | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | 0.670 |
ftsQ | ftsZ | Rv2151c | Rv2150c | Possible cell division protein FtsQ; Essential cell division protein. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.991 |
ftsQ | pbpA | Rv2151c | Rv0016c | Possible cell division protein FtsQ; Essential cell division protein. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.968 |
ftsQ | pknA | Rv2151c | Rv0015c | Possible cell division protein FtsQ; Essential cell division protein. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.591 |
ftsQ | pknB | Rv2151c | Rv0014c | Possible cell division protein FtsQ; Essential cell division protein. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.670 |
ftsQ | ponA2 | Rv2151c | Rv3682 | Possible cell division protein FtsQ; Essential cell division protein. | PASTA domain-containing protein; Rv3682, (MTV025.030), len: 810 aa. Probable ponA2,penicillin-binding protein (class A), bienzymatic membrane-associated protein with transglycosylase and transpeptidase activities. Almost identical to Q9CB85|PON1|ML2308 penicillin binding protein (class A) from Mycobacterium leprae (803 aa) FASTA scores: opt: 4743,E(): 3.3e-217, (87.7% identity in 806 aa overlap); or P72351|PON1|PBP1 high-molecular-mass class a penicillin binding protein from Mycobacterium leprae Cosmid B577 (821 aa), FASTA scores: opt: 4547, E(): 6.3e-208, (88.05% identity in 769 aa ov [...] | 0.569 |
ftsQ | sepF | Rv2151c | Rv2147c | Possible cell division protein FtsQ; Essential cell division protein. | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. | 0.980 |
ftsQ | wag31 | Rv2151c | Rv2145c | Possible cell division protein FtsQ; Essential cell division protein. | Diviva family protein Wag31; Important for maintaining cell shape and cell wall integrity by localizing peptidoglycan synthesis to the cell poles. Protects PbpB (PBP3, FtsI) from oxidative stress-induced cleavage. | 0.970 |
ftsZ | cwsA | Rv2150c | Rv0008c | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Possible membrane protein; Required for regulated cell division, cell wall synthesis and the maintenance of cell shape; Belongs to the CwsA family. | 0.694 |
ftsZ | ftsQ | Rv2150c | Rv2151c | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Possible cell division protein FtsQ; Essential cell division protein. | 0.991 |
ftsZ | pbpA | Rv2150c | Rv0016c | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Probable penicillin-binding protein PbpA; Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation; Belongs to the transpeptidase family. | 0.779 |
ftsZ | pknA | Rv2150c | Rv0015c | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as FtsZ, Wag31, GlmU, FhaB, PstP, EmbR and Rv1422. Also catalyzes the phosphorylation of the proteasome alpha-subunit (PrcA) and unprocessed proteasome beta-subunit (pre-PrcB), which results in the inhibitio [...] | 0.851 |
ftsZ | pknB | Rv2150c | Rv0014c | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B); Protein kinase that regulates many aspects of mycobacterial physiology, and is critical for growth in vitro and survival of the pathogen in the host. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Also catalyzes the phosphorylation of the core proteasome alpha-subunit (PrcA), and thereby regulates th [...] | 0.819 |