node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv2269c | cyp124 | Rv2269c | Rv2266 | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | 0.546 |
Rv2269c | cyp128 | Rv2269c | Rv2268c | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.968 |
Rv2269c | lppN | Rv2269c | Rv2270 | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | 0.573 |
Rv2269c | stf3 | Rv2269c | Rv2267c | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.968 |
cyp124 | Rv2269c | Rv2266 | Rv2269c | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.546 |
cyp124 | cyp128 | Rv2266 | Rv2268c | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.548 |
cyp124 | stf3 | Rv2266 | Rv2267c | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.721 |
cyp128 | Rv2269c | Rv2268c | Rv2269c | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.968 |
cyp128 | cyp124 | Rv2268c | Rv2266 | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | 0.548 |
cyp128 | lppN | Rv2268c | Rv2270 | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | 0.570 |
cyp128 | stf3 | Rv2268c | Rv2267c | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.998 |
lppN | Rv2269c | Rv2270 | Rv2269c | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.573 |
lppN | cyp128 | Rv2270 | Rv2268c | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.570 |
lppN | stf3 | Rv2270 | Rv2267c | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | 0.556 |
stf3 | Rv2269c | Rv2267c | Rv2269c | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | Hypothetical protein; Rv2269c, (MTCY339.41), len: 110 aa. Unknown protein; questionable ORF. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007). | 0.968 |
stf3 | cyp124 | Rv2267c | Rv2266 | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | Probable cytochrome P450 124 Cyp124; Primarily hydroxylates the omega-carbon of a number of methyl-branched lipids, including (2E,6E)-farnesol, phytanate, geranylgeraniol, 15-methylpalmitate and (2E,6E)-farnesyl diphosphate. Also catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. Cyp124 catalyzes preferencially the oxidation of (25R)-26-hydroxycholest-4-en-3-one diastereomer. Also able to sequen [...] | 0.721 |
stf3 | cyp128 | Rv2267c | Rv2268c | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | Rv2268c, (MT2330, MTCY339.42), len: 489 aa. Probable cyp128, cytochrome P450, similar to (but longer than) cytochrome p-450 e.g. CPXK_SACER P3 3271 cytochrome p-450 107b1 (405 aa), FASTA scores, opt: 620, E(): 8.3e-33,(31.8% identity in 406 aa overlap); contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature,similar to MTCY50.26, 32.7% identity in 382 aa overlap. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007). | 0.998 |
stf3 | lppN | Rv2267c | Rv2270 | Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family. | Probable lipoprotein LppN; Probably involved in bacterial recognition and uptake by its host (human). | 0.556 |