Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Rv2425cRv2425c, (MTCY428.22), len: 480 aa. Hypothetical protein; C-terminal half shares similarity to other unknown conserved proteins e.g. Q53065 hypothetical 24.3 KDA protein from Rhodococcus erythropolis (219 aa), FASTA scores: opt: 398, E(): 9.9e-17, (34.15% identity in 202 aa overlap); C-terminus of O27843|MTH1815 conserved protein from Methanothermobacter thermautotrophicus (346 aa), FASTA scores: opt: 341, E(): 3.7e-13, (31.35% identity in 233 aa overlap); etc. (480 aa)    
Predicted Functional Partners:
Rv2426c
Rv2426c, (MTCY428.21), len: 291 aa. Conserved hypothetical protein, highly similar to others e.g. Q51326|ORF4 from Pseudomonas carboxydovorans (295 aa),FASTA scores: opt: 853, E(): 3.7e-43, (48.75% identity in 277 aa overlap); BAB47746|MLR0088 from Rhizobium loti (309 aa), FASTA scores: opt :809, E(): 1.5e-40, (46.5% identity in 291 aa overlap); Q9Y9R8|APE2220 from Aeropyrum pernix (297 aa), FASTA scores: opt: 763, E(): 7.4e-38, (47.1% identity in 261 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
 
    0.972
mobA
Probable molybdopterin-guanine dinucleotide biosynthesis protein A MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
  
   
 0.914
Rv2456c
Rv2456c, (MTV008.12c), len: 418 aa. Probable conserved integral membrane transport protein, involved in a efflux system, weakly similar to many e.g. Q9RUR0|YD22_DEIRA|DR1322 putative sugar efflux transporter from Deinococcus radiodurans (389 aa), FASTA scores: opt: 224, E(): 8.4e-06, (24.45% identity in 409 aa overlap); Q9UYY0|PAB0913 multidrug resistance protein from Pyrococcus abyssi (410 aa), FASTA scores: opt: 210, E(): 5.6e-05,(21.8% identity in 408 aa overlap); etc. Contains PS00216 Sugar transport proteins signature 1.
   
  
 0.905
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
  
    0.803
Rv0370c
Rv0370c, (MTV036.05c), len: 298 aa. Possible oxidoreductase, similar to many hypothetical proteins, but also similar to ORF4|X82447|OCCOXMSL4_4 Protein of coxMSL gene cluster from Pseudomonas/Oligotropha carboxidovorans (295 aa), FASTA scores: opt: 851, E(): 0, (48.2% identity in 282 aa overlap); AJ224684|BJAJ4684_3 cooxS from Bradyrhizobium japonicum (302 aa), FASTA scores: opt: 881,E(): 0, (47.6% identity in 290 aa overlap). Also highly similar to MTCY428_21 from Mycobacterium tuberculosis. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
 
     0.745
mftF
Probable membrane sugar transferase; May play a role in the maturation of mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the glycosyltransferase 2 family.
 
    0.609
Rv2417c
Conserved protein; May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism.
 
    0.583
Rv2424c
Probable transposase; Rv2424c, (MTCY428.23), len: 333 aa. Probable transposase for IS1558, similar to is element proteins e.g. AL021957|Rv2177c|MTV021_10 from Mycobacterium tuberculosis (221 aa), FASTA scores: opt: 1491, E(): 6.2e-87, (98.6% identity in 221 aa overlap); P19780|YIS1_STRCO hypothetical insertion element IS110 from Streptomyces coelicolor (45 aa), FASTA scores: opt: 203, E(): 1.7e-05; (27.3% identity in 238 aa overlap); etc. Contains PS01159 WW/rsp5/WWP domain signature.
  
    0.565
pqqE
Probable coenzyme PQQ synthesis protein E PqqE (coenzyme PQQ synthesis protein III); May function to modify mycofactocin, a conserved polypeptide that might serve as an electron carrier. The genes for mycofactocin and other proteins proposed to function in its maturation are found in a conserved gene cluster; Belongs to the radical SAM superfamily.
 
    0.560
Rv0368c
Rv0368c, (MTV036.03c), len: 403 aa. Conserved hypothetical protein, showing some similarity to AJ224684|BJAJ4684_4 cooxS protein from Bradyrhizobium japonicum (422 aa), FASTA scores: opt: 341, E(): 4.3e-13,(27.4% identity in 387 aa overlap); Rv2425c|MTCY428_22 hypothetical protein from Mycobacterium tuberculosis FASTA score: (30.7% identity in 238 aa overlap). Contains PS00213 Lipocalin signature.
  
     0.518
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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