Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
Rv2676cConserved protein; Rv2676c, (MTCY441.45c), len: 231 aa. Conserved protein, equivalent to Q9CCB2|ML1045 (alias Q50009|U1764Y but longer 66 aa) hypothetical protein from Mycobacterium leprae (231 aa), FASTA scores: opt: 1401, E(): 8.7e-88,(87.45% identity in 231 aa overlap). Also highly similar to O69830|SC1B5.02 hypothetical 28.1 KDA protein from Streptomyces coelicolor (243 aa), FASTA scores: opt: 915,E(): 7.7e-55, (61.25% identity in 222 aa overlap); and similar to others e.g. Q9RUB0|DR1481 conserved hypothetical protein from Deinococcus radiodurans (289 aa), FASTA scores: opt: 327, E [...] (231 aa)    
Predicted Functional Partners:
hemZ
Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase); Involved in the biosynthesis of heme. Catalyzes the ferrous insertion into protoporphyrin IX to form protoheme.
 
 0.996
ctaB
Probable cytochrome C oxidase assembly factor CtaB; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
  
 
 0.920
hemY
Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
  
  
 0.920
hemE
Probable uroporphyrinogen decarboxylase HemE (uroporphyrinogen III decarboxylase) (URO-D) (UPD); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.917
glyS
Probable glycyl-tRNA synthetase GlyS (glycine--tRNA ligase) (GLYRS); Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family.
      
 0.889
gatB
Probable glutamyl-tRNA(GLN) amidotransferase (subunit B) GatB (Glu-ADT subunit B); Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily.
   
  
 0.857
Rv2680
Conserved protein; Rv2680, (MTV010.04), len: 210 aa. Conserved protein,equivalent to Q50005|ML1041|U1764V hypothetical protein from Mycobacterium leprae (196 aa), FASTA scores: opt: 1136, E(): 9.7e-66, (83.95% identity in 193 aa overlap). Also similar to O69860|SC1C3.18c hypothetical 24.7 KDA protein from Streptomyces coelicolor (238 aa), FASTA scores: opt: 516, E(): 5.7e-26, (45.5% identity in 189 aa overlap); and similar in part to Q9I6V4|PA0178 probable two-component sensor from Pseudomonas aeruginosa (639 aa),FASTA scores: opt: 120, E(): 3.1, (33.05% identity in 115 aa overlap); an [...]
 
    0.811
Rv2675c
Rv2675c, (MTCY441.44c), len: 250 aa. Conserved hypothetical protein. C-terminus highly similar to Q50010|U1764Z from Mycobacterium leprae (69 aa), FASTA scores: opt: 284, E(): 4.6e-11, (68.25% identity in 63 aa overlap). Shows some similarity with Q9P3V6|SPAC1348.04 (alias Q9P3E7|Q9P7U5) hypothetical 16.6 KDA protein from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 203, E(): 9.5e-06, (33.05% identity in 118 aa overlap); Q9ZSZ7|BMCT methyl chloride transferase from Batis maritima (230 aa), FASTA scores: opt: 197, E(): 3.3e-05, (28.85% identity in 156 aa overla [...]
  
    0.787
echA15
Probable enoyl-CoA hydratase EchA15 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase); Rv2679, (MTV010.03), len: 276 aa. Probable echA15,enoyl-CoA hydratase, similar to P53526|ECHC_MYCLE|ECHA12|ML1241|MLCB1610.01|B1170_C2_224 probable enoyl-CoA hydratase from Mycobacterium leprae (294 aa), FASTA scores: opt: 368, E(): 2.5e-16, (32.15% identity in 277 aa overlap). Also highly similar to Q9RXX1|DR0184 from Deinococcus radiodurans (273 aa), FASTA scores: opt: 993, E(): 2.2e-56, (58.15% identity in 263 aa overlap); and similar to many e.g. Q9ETY7|PACA|PAAG from Azoarcus evansii [...]
  
    0.770
ettA
Probable macrolide-transport ATP-binding protein ABC transporter; A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.
      
 0.686
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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