Possible conserved membrane protein; Cell wall hydrolase that modulates cell division process. Probably acts by modulating FtsZ ring assembly. Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis. Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ.

Rv1158c, (MTCI65.25c), len: 227 aa. Conserved hypothetical Ala-, Pro-rich protein, similar to other proline rich proteins and extensins e.g. MMSAP62|g633250 house mouse (485 aa), FASTA scores: opt: 367, E(): 1.2e-08,(36.3% identity in 212 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).

Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.

Rv1988, (MTCY39.31c), len: 179 aa. Probable erm(37),23S rRNA methyltransferase, similar to ERME_SACER|P07287 rrna adenine n-6-methyltransferase (370 aa), FASTA scores: opt: 259, E(): 2e-11, (35.1% identity in 171 aa overlap); contains PS00092 N-6 Adenine-specific DNA methylases signature. Also similar to Mycobacterium tuberculosis Rv1010 ksgA 16S rRNA dimethyltransferase. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007); Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

PE-PGRS family protein PE_PGRS37; Rv2126c, (MTCY261.22c), len: 256 aa. PE_PGRS37,Possible PE_PGRS pseudogene fragment, similar to the Gly-rich C-terminus of many members of the Mycobacterium tuberculosis PGRS family.

Repressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Has been shown to bind to the 14 bp palindromic sequence 5'-CGAACNNNNGTTCG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.

GCN5-related N-acetyltransferase, MshD; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. Belongs to the acetyltransferase family. MshD subfamily.

Probable dehydrogenase; Rv3829c, (MTCY409.01, MTCY01A6.40), len: 536 aa. Probable oxidoreductase dehydrogenase, similar to others e.g. Q9A3T1|CC3121 phytoene dehydrogenase-related protein from Caulobacter crescentus (543 aa), FASTA scores: opt: 607, E(): 9.2e-28, (28.25% identity in 552 aa overlap); Q98FP6|MLR3676 phytoene dehydrogenase from Rhizobium loti (Mesorhizobium loti) (521 aa), FASTA scores: opt: 605, E(): 1.2e-27, (28.2% identity in 546 aa overlap); Q97W24|SSO2422 phytoene dehydrogenase related protein from Sulfolobus solfataricus (518 aa), FASTA scores: opt: 388, E(): 4.4e-1 [...]

Probable lipase LipE; Rv3775, (MTCY13D12.09), len: 415 aa. Probable lipE,hydrolase lipase, equivalent to Q9CD95|LIPE|ML0119 probable hydrolase from Mycobacterium leprae (411 aa), FASTA scores: opt: 2418, E(): 6.4e-144, (84.75% identity in 406 aa overlap). Also similar to other esterases e.g. Q9ABH2|CC0255 esterase a from Caulobacter crescentus (374 aa), FASTA scores: opt: 427, E(): 2.4e-19, (28.9% identity in 391 aa overlap); O87861|ESTA esterase a from Streptomyces chrysomallus (389 aa), FASTA scores: opt: 417,E(): 1e-18, (31.0% identity in 361 aa overlap); Q9RK50|SCF12.08 putative es [...]