STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2771cRv2771c, (MTV002.36c), len: 150 aa. Conserved hypothetical protein, equivalent to Q9CBV8|ML1525 hypothetical protein from Mycobacterium leprae (151 aa),FASTA scores: opt: 489, E(): 1.7e-27, (52.7% identity in 148 aa overlap). Also highly similar to Q9RD46|SCF56.21 hypothetical 15.7 KDA protein from Streptomyces coelicolor (151 aa), FASTA scores: opt: 671, E(): 2.2e-40, (67.8% identity in 146 aa overlap). (150 aa)    
Predicted Functional Partners:
Rv2772c
Rv2772c, (MTV002.37c), len: 157 aa. Probable conserved transmembrane protein, equivalent to Q9CBV7|ML1526 conserved membrane protein from Mycobacterium leprae (160 aa), FASTA scores: opt: 767, E(): 1.5e-43,(76.6% identity in 154 aa overlap); and similar to P46830|YDAB_MYCBO from Mycobacterium bovis (177 aa), FASTA scores: opt: 337, E(): 3.9e-15, (40.75% identity in 135 aa overlap). Also similar to O86837|SC9A10.04 putative membrane protein from Streptomyces coelicolor (151 aa),FASTA scores: opt: 338, E(): 3e-15, (43.75% identity in 144 aa overlap). A core mycobacterial gene; conserved [...]
 
    0.815
dapB
Dihydrodipicolinate reductase DapB (DHPR); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Can use both NADH and NADPH as a reductant, with NADH being 6-fold as effective as NADPH.
  
  
 0.792
Rv0007
Rv0007, (MTCY10H4.05), len: 304 aa. Possible conserved membrane protein. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al.,2004).
   
  
 0.660
Rv2774c
Hypothetical protein; Rv2774c, (MTV002.39c), len: 134 aa. Hypothetical unknown protein.
  
    0.548
PPE44
Rv2770c, (MTV002.35c), len: 382 aa. PPE44, Member of the Mycobacterium tuberculosis PPE family, highly similar to many e.g. downstream ORF O33310|Rv2768c|MTV002.33c from M. tuberculosis (394 aa), FASTA scores: opt: 1135, E(): 2.2e-53, (62.15% identity in 391 aa overlap); and P96362|Rv1039c|MTCY10G2.10 from Mycobacterium tuberculosis (391 aa), FASTA scores: opt: 1010, E(): 1e-46, (55.95% identity in 395 aa overlap). Equivalent to AAK47159 from Mycobacterium tuberculosis strain CDC1551 (402 aa) but shorter 20 aa. Start changed since first submission (-20 aa).
  
    0.513
rpfC
Probable resuscitation-promoting factor RpfC; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity. Belongs to the transglycosylase family. Rpf subfamily.
  
  
 0.468
rpfE
Probable resuscitation-promoting factor RpfE; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity. Belongs to the transglycosylase family. Rpf subfamily.
  
  
 0.464
tkt
Transketolase Tkt (TK); Catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate. Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. Belongs to the transketolase family.
  
  
 0.457
rpfD
Probable resuscitation-promoting factor RpfD; Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity. Belongs to the transglycosylase family. Rpf subfamily.
   
  
 0.444
sodC
Periplasmic superoxide dismutase [Cu-Zn] SodC; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. May play a role in favoring mycobacterial survival in phagocytes (By similarity).
  
  
 0.441
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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