STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv2886cProbable resolvase; Rv2886c, (MTCY274.17c), len: 295 aa. Probable resolvase for IS1539. Contains PS00213 Lipocalin signature. (295 aa)    
Predicted Functional Partners:
Rv2885c
Probable transposase; Rv2885c, (MTCY274.16c), len: 460 aa. Probable transposase for IS1539. Contains PS00017 ATP/GTP-binding site motif A (P-loop); In the N-terminal section; belongs to the transposase 2 family.
 
  
 0.948
Rv0922
Possible transposase; Rv0922, (MTCY21C12.16), len: 550 aa. Possible transposase for IS1535, similar to many e.g. YX16_MYCTU|Q10809|MTCY274.16c from Mycobacterium tuberculosis (460 aa), FASTA scores: opt 939, E(): 0,(40.6% identity in 465 aa overlap); etc.
 
  
 0.786
Rv3827c
Possible transposase; Rv3827c, (MTCY409.03), len: 408 aa. Possible transposase within IS1537 element, similar to several transposases e.g. O83029|TNPC|DR2324|DR0666|DR0978|DR1381|DR1651|DR1933 transposase from Deinococcus radiodurans(408 aa) FASTA scores: opt: 302, E(): 3.9e-12, (30.75% identity in 358 aa overlap); Q9RXX7|DR0178 putative transposase from Deinococcus radiodurans (409 aa), FASTA scores: opt: 297,E(): 8.2e-12, (31.1% identity in 360 aa overlap); P73816|SLR2062 transposase from Synechocystis sp. strain PCC 6803 (400 aa), FASTA scores: opt: 296, E(): 9.3e-12,(30.05% identit [...]
 
  
 0.780
Rv2978c
Probable transposase; Rv2978c, (MTCY349.09), len: 459 aa. Probable transposase for IS1538, very similar to several other putative transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809 (460 aa), FASTA scores: opt: 2613, E(): 0, (83.0% identity in 458 aa overlap); etc. Low level matches to other tranposases.
 
  
 0.777
Rv0606
Possible transposase (fragment); Rv0606, (MTCY19H5.16c), len: 247 aa. Possible truncated transposase for IS_1536 element, highly similar to N-terminus of other transposases from Mycobacterium tuberculosis e.g. YX16_MYCTU|Q10809|Rv2885c|MT2953|MTCY274.16c putative transposase from Mycobacterium tuberculosis (460 aa), FASTA scores: opt: 1368, E(): 0, (83.5% identity in 237 aa overlap); Rv2978c, Rv0922, Rv3827c, etc. Also similar to N-terminus of MTV002_57|Rv2792 resolvase from M. tuberculosis (193 aa), FASTA score: (87.4% identity in 238 aa overlap). This region is a possible MT-complex- [...]
 
  
 0.775
Rv2791c
Probable transposase; Rv2791c, (MTV002.56c), len: 459 aa. Probable IS1602 transposase for IS1602 element, similar to many e.g. P95117|Rv2978c|MTCY349.09 from Mycobacterium tuberculosis (459 aa), FASTA scores: opt: 2718, E(): 6.3e-165, (86.05% identity in 459 aa overlap).
 
  
 0.775
Rv2956
Conserved protein; Rv2956, (MTCY349.33c), len: 243 aa. Conserved protein, highly similar to O86299|GSC GSC protein from Mycobacterium avium subsp. silvaticum Mycobacterium avium (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap); and O86294|GSC GSC protein from Mycobacterium paratuberculosis (240 aa), FASTA scores: opt: 1070, E(): 3.5e-63, (67.5% identity in 240 aa overlap). Also some similarity with other proteins from other organisms e.g. Q9L727 nodulation protein NOEI from Rhizobium fredii (Sinorhizobium fredii) (241 aa), FASTA scores: opt: 205, E(): [...]
  
  
 0.601
Rv3334
Rv3334, (MTV016.34), len: 146 aa. Probable transcriptional regulator, similar to many regulatory proteins (notably mercury resistance operon regulators) e.g. Q9HXV1|PA3689 probable transcriptional regulator MerR family from Pseudomonas aeruginosa (156 aa), FASTA scores: opt: 275, E(): 1.6e-11, (35.95% identity in 139 aa overlap); Q9AKR6|PBRR lead resistance operon regulator from Ralstonia metallidurans strain CH34 (plasmid pMOL30) (145 aa), FASTA scores: opt: 267, E(): 5.2e-11, (35.8% identity in 134 aa overlap); P95838|MERR mercuric resistance operon regulator from Synechococcus sp. s [...]
   
  
 0.590
Rv0401
Rv0401, (MTCY04D9.14), len: 123 aa. Probable conserved transmembrane protein, equivalent to AL023514|MLCB4_9 putative integral membrane protein from Mycobacterium leprae (122 aa), FASTA scores: opt: 548, E(): 4.4e-32, (66.9% identity in 121 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
   
  
 0.586
Rv2566
Long conserved protein; Rv2566, (MTCY9C4.02c), len: 1140 aa. Long conserved protein, equivalent to O53120|ML2678 or MLCB1913.12 hypothetical protein from Mycobacterium leprae (1000 aa),FASTA scores: opt: 760, E(): 7.1e-38, (50.2% identity in 1128 aa overlap); and middle part equivalent to Q9ZB40 72.2 KDA protein (fragment) from Mycobacterium leprae (644 aa),FASTA scores: opt: 1017, E(): 1.5e-65, (45.65% identity in 655 aa overlap). Also highly similar to Q98HG6|MLL2877 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (1119 aa), FASTA scores: opt: 1413, E(): 3.7e-77,(52.4% [...]
   
  
 0.580
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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