STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3023cProbable transposase; Rv3023c, (MTV012.38c), len: 415 aa. Probable IS1081 transposase. Contains PS01007 Transposases, Mutator family,signature. Similars to P35882|TRA1_MYCTU|Rv1199c|MTCI364.11c and Rv2512c|MTCY07A7.18c transposases for insertion sequence element IS1081 (415 aa), FASTA scores: opt: 2675, E(): 1.8e-162, (100.0% identity in 415 aa overlap). Belongs to the mutator family of transposase. (415 aa)    
Predicted Functional Partners:
Rv3530c
Rv3530c, (MTCY03C7.26), len: 260 aa. Possible oxidoreductase, similar to various oxidoreductases and hypothetical proteins e.g. BAB53258|Q987E5|MLL7083 probable oxidoreductase from Rhizobium loti (Mesorhizobium loti) (258 aa), FASTA scores: opt: 405, E(): 5.3e-18, (33.45% identity in 263 aa overlap); Q9VNF3|CG12171 hypothetical protein from Drosophila melanogaster (Fruit fly) (257 aa),FASTA scores: opt: 404, E(): 6.1e-18, (32.8% identity in 256 aa overlap); Q9A3X5|CC3076 oxidoreductase (short-chain dehydrogenase/reductase family) from Caulobacter crescentus (254 aa), FASTA scores: opt: [...]
      
 0.870
Rv3531c
Hypothetical protein; Rv3531c, (MTCY03C7.25), len: 375 aa. Hypothetical unknown protein.
   
  
 0.870
Rv1047
Probable transposase; Required for the transposition of the insertion element.
  
   
0.852
Rv2512c
Rv2512c, (MTCY07A7.18c), len: 415 aa. Transposase for IS1081, identical to P35882|TRA1_MYCBO transposase for insertion sequence element IS1081 from Mycobacterium bovis (415 aa), FASTA scores: opt: 2680, E(): 1.9e-162, (100.0% identity in 415 aa overlap). Also highly similar to others from Mycobacterium tuberculosis e.g. P96354|Rv1047|MTCY10G2.02c|Rv3115|MTCY164.25|Rv3023c|MTV01 2.38c (415 aa), FASTA scores: opt: 2675, E(): 3.9e-162, (99.75% identity in 415 aa overlap). Contains PS00435 Peroxidases proximal heme-ligand signature, PS01007 Transposases,Mutator family, signature. Belongs t [...]
  
   
0.845
Rv1199c
Possible transposase; Required for the transposition of the insertion element.
  
   
0.841
Rv3115
Probable transposase; Rv3115, (MTCY164.25), len: 415 aa. Probable IS1081 transposase, similar to others. Has transposases, mutator family, signature (PS01007). Other copies are MTCY10G2.02c,MTCY441.35, MTCY77.03c. This region is a possible MT-complex-specific genomic island (See Becq et al.,2007).
  
   
0.839
Rv2666
Probable transposase for insertion sequence element IS1081 (fragment); Required for the transposition of the insertion element.
  
   
0.818
vapC25
Possible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB25.; Belongs to the PINc/VapC protein family.
   
  
 0.553
vapC29
Possible toxin VapC29. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. Its cognate antitoxin is VapB29 (By similarity). Has ribonuclease activity.
   
  
 0.517
iscS
IscS-like cysteine desulfurase; Catalyzes the removal of elemental sulfur from cysteine to produce alanine (Probable). Participates in the biosynthesis of metalloclusters by providing the inorganic sulfur required for Fe-S core formation. One acceptor is Whib3, on which this enzyme assembles a 4Fe-4S cluster. It can use both L-cysteine and L-selenocysteine as substrates.
  
    0.475
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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