Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Rv0142 | mymA | Rv0142 | Rv3083 | Rv0142, (MTCI5.16), len: 308 aa. Conserved hypothetical protein, similar, except in N-terminus, to AB88922.1|AL353862 hypothetical protein SCE34.20 from Streptomyces coelicolor (326 aa). | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.631 |
| Rv3087 | adhD | Rv3087 | Rv3086 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.977 |
| Rv3087 | fadD13 | Rv3087 | Rv3089 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | 0.989 |
| Rv3087 | lipR | Rv3087 | Rv3084 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.976 |
| Rv3087 | mymA | Rv3087 | Rv3083 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.987 |
| Rv3087 | sadH | Rv3087 | Rv3085 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Probable short-chain type dehydrogenase/reductase; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.970 |
| Rv3087 | tgs4 | Rv3087 | Rv3088 | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA. | 0.988 |
| Rv3087 | virS | Rv3087 | Rv3082c | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | Virulence-regulating transcriptional regulator VirS (AraC/XylS family); Regulates the expression of the mymA operon (Rv3083-Rv3089). | 0.641 |
| adhD | Rv3087 | Rv3086 | Rv3087 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | 0.977 |
| adhD | fadD13 | Rv3086 | Rv3089 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | 0.983 |
| adhD | lipR | Rv3086 | Rv3084 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.991 |
| adhD | mymA | Rv3086 | Rv3083 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.982 |
| adhD | nrdB | Rv3086 | Rv0233 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Ribonucleoside-diphosphate reductase (beta chain) NrdB (ribonucleotide reductase small chain); Probable oxidase that might be involved in lipid metabolism. | 0.730 |
| adhD | sadH | Rv3086 | Rv3085 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Probable short-chain type dehydrogenase/reductase; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.991 |
| adhD | tgs4 | Rv3086 | Rv3088 | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs4; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has very weak wax synthase activity, incorporating palmityl alcohol into wax esters in the presence of palmitoyl-CoA. | 0.978 |
| adhD | virS | Rv3086 | Rv3082c | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | Virulence-regulating transcriptional regulator VirS (AraC/XylS family); Regulates the expression of the mymA operon (Rv3083-Rv3089). | 0.521 |
| ethA | mymA | Rv3854c | Rv3083 | Monooxygenase EthA; Monooxygenase able to convert a wide range of ketones to the corresponding esters or lactones via a Baeyer-Villiger oxidation reaction. Can act on long-chain aliphatic ketones (2-hexanone to 2- dodecanone) and on aromatic ketones (phenylacetone and benzylacetone). Is also able to catalyze enantioselective sulfoxidation of methyl-p- tolylsulfide. In vivo, likely functions as a BVMO, but the exact nature of the physiological substrate(s) remains to be established. | Probable monooxygenase (hydroxylase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the FAD-binding monooxygenase family. | 0.906 |
| fadD13 | Rv3087 | Rv3089 | Rv3087 | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | Possible triacylglycerol synthase (diacylglycerol acyltransferase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Upon expression in E.coli functions weakly as a triacylglycerol synthase, making triacylglycerol (TG) from diolein and long-chain fatty acyl-CoA. Has no wax synthase activity. | 0.989 |
| fadD13 | adhD | Rv3089 | Rv3086 | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH; Belongs to the zinc-containing alcohol dehydrogenase family. | 0.983 |
| fadD13 | lipR | Rv3089 | Rv3084 | Probable chain-fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase); Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. Catalyzes the activation of long-chain fatty acids as acyl-coenzyme A (acyl-CoA), which are then transferred to the multifunctional polyketide synthase (PKS) type III for further chain extension. It has preference for the fatty acid with long chain length in the following order: hexacosanoic acid (C26), tetracosanoic acid (C24) and palmitic acid (C16); Belongs to the ATP-dependent AMP-bi [...] | Probable acetyl-hydrolase/esterase LipR; Required for maintaining the appropriate mycolic acid composition and permeability of the envelope on its exposure to acidic pH. | 0.988 |
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