STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3166cConserved hypothetical protein; Rv3166c, (MTV014.10c), len: 319 aa. Probable transmembrane protein, similar but longer (52 aa) to O32895|MLCB1779.35c hypothetical protein from Mycobacterium leprae (119 aa), FASTA scores: opt: 289, E(): 3.7e-10,(44.25% identity in 122 aa overlap). Also some similarity to Q9Z536|SC9B2.23c putative transmembrane protein from Streptomyces coelicolor (339 aa), FASTA scores: opt: 247,E(): 2.5e-07, (28.2% identity in 326 aa overlap); and in N-terminus to Q9RS20|DR2307 putative multidrug-efflux transporter from Deinococcus radiodurans (410 aa), FASTA scores: o [...] (319 aa)    
Predicted Functional Partners:
Rv3163c
Rv3163c, (MTV014.07c), len: 423 aa. Possible conserved secreted protein, with some similarity to other hypothetical bacterial proteins e.g. Q9Z539|SC9B2.20c from Streptomyces coelicolor (460 aa), FASTA scores: opt: 666,E(): 1.5e-33, (33.55% identity in 417 aa overlap); O58486|PH0774 from Pyrococcus horikoshii (410 aa), FASTA scores: opt: 329, E(): 6.9e-13, (23.8% identity in 424 aa overlap); Q9UZ66|PAB0849 from Pyrococcus abyssi (410 aa),FASTA scores: opt: 322, E(): 1.9e-12, (24.15% identity in 389 aa overlap); etc. Also some similarity with P71761|Rv1480|MTV007.27|MTCY277.01 from Myco [...]
 
     0.961
Rv3165c
Unknown protein; Rv3165c, (MTV014.09)c, len: 160 aa. Unknown protein.
  
    0.908
moxR3
Rv3164c, (MTV014.08c), len: 320 aa. Probable moxR3,methanol dehydrogenase regulatory protein, highly similar to Q9Z538|SC9B2.21c putative regulatory protein from Streptomyces coelicolor (332 aa), FASTA scores: opt: 1227,E(): 1.7e-67, (60.25% identity in 302 aa overlap); Q9UZ67|MOXR-3|PAB0848 methanol dehydrogenase regulatory protein from Pyrococcus abyssi (314 aa), FASTA scores: opt: 1126, E(): 2.3e-61, (54.1% identity in 305 aa overlap); Q9HSH7|MOXR|VNG0223G methanol dehydrogenase regulatory protein from Halobacterium sp. strain NRC-1 (318 aa), FASTA scores: opt: 1072, E(): 4.5e-58, ( [...]
  
    0.881
Rv3162c
Rv3162c, (MTV014.06c), len: 145 aa. Possible integral membrane protein, with some similarity to C-terminal part of Q10803|Rv2877c|MTCY274.08c hypothetical protein from Mycobacterium tuberculosis (287 aa), FASTA scores: opt: 112, E(): 6.9, (29.65% identity in 135 aa overlap); and other hypothetical proteins from other organisms.
  
    0.842
Rv2423
Hypothetical protein; Rv2423, (MTCY428.24c), len: 348 aa. Hypothetical unknown protein.
 
    0.765
Rv3899c
Rv3899c, (MTCY15F10.13), len: 410 aa. Conserved hypothetical protein, similar in part to proteins from Mycobacterium tuberculosis strains H37Rv and CDC1551. Region between aa 29-80 is strictly identical to P96909 hypothetical 15.1 KDA protein (fragment) (143 aa) FASTA scores: opt: 562, E(): 4e-16, (69.0% identity in 142 aa overlap); and the N-terminal end is highly similar, but longer 65 aa, to O07266 hypothetical 13.7 KDA protein (fragment) (143 aa), FASTA scores: opt: 562, E(): 4e-16,(69.0% identity in 142 aa overlap). Highly similar to C-terminal end of Q10690|YK82_MYCTU|Rv2082|MTCY [...]
  
     0.758
Rv3099c
Conserved protein; Rv3099c, (MTCY164.10c), len: 283 aa. Conserved protein, some similarity with hypothetical proteins e.g. Q9XA69|SCGD3.09 from Streptomyces coelicolor (274 aa),FASTA scores: opt: 384, E(): 1.8e-17, (32.7% identity in 269 aa overlap); and P71606|Y036_MYCTU|Rv0036c from Mycobacterium tuberculosis strain H37Rv (257 aa), FASTA scores: opt: 179, E(): 0.00024, (25.85% identity in 205 aa overlap).
  
     0.745
Rv3435c
Rv3435c, (MTCY77.07c), len: 284 aa. Probable conserved transmembrane protein, showing some similarity with P95061|Rv0713|MTCY210.32 hypothetical 33.9 KDA protein from Mycobacterium tuberculosis (313 aa), FASTA scores: opt: 557, E(): 1.3e-26, (35.8% identity in 282 aa overlap); and O32991|MLCB2492.12 from Mycobacterium leprae (95 aa),FASTA scores: opt: 150, E(): 0.022, (35.3% identity in 85 aa overlap). Equivalent to AAK47881 from Mycobacterium tuberculosis strain CDC1551 (312 aa) but shorter 28 aa.
  
     0.745
Rv3843c
Rv3843c, (MTCY01A6.26), len: 342 aa. Probable conserved transmembrane protein, equivalent to Q9CDC6|ML0073 putative membrane protein from Mycobacterium leprae (344 aa), FASTA scores: opt: 1420, E(): 2.6e-68,(63.05% identity in 349 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
  
     0.728
Rv1006
Unknown protein; Rv1006, (MTCI237.23), len: 567 aa. Unknown protein. Predicted to be an outer membrane protein (See Song et al.,2008).
  
     0.714
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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