STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3201cRv3201c, (MTV014.45c), len: 1101 aa. Probable ATP-dependent DNA helicase, similar to others e.g. Q9FCK4|2SC3B6.08 from Streptomyces coelicolor (1222 aa),FASTA scores: opt: 1209, E(): 5.4e-63, (38.45% identity in 1199 aa overlap); P71561|PCRA_MYCTU|CRA|IVRD|Rv0949|MT0976|MTCY10D7.25c from Mycobacterium tuberculosis (771 aa), FASTA scores: opt: 403, E(): 6.5e-16, (28.15% identity in 717 aa overlap); Q9FCK5|2SC3B6.07 from Streptomyces coelicolor (1159 aa),FASTA scores: opt: 349, E(): 1.3e-12, (29.2% identity in 1144 aa overlap); Q9L3M1|UVRD from Prochlorococcus sp. (512 aa; fragment), FAS [...] (1101 aa)    
Predicted Functional Partners:
Rv3202c
Possible ATP-dependent DNA helicase; Rv3202c, (MTCY07D11.24, MTV014.46c), len: 1055 aa. Possible ATP-dependent DNA helicase, showing some similarity to UvrD proteins e.g. Q9FCK5|2SC3B6.07 putative ATP-dependent DNA helicase from Streptomyces coelicolor (1159 aa), FASTA scores: opt: 666, E(): 1e-29, (34.5% identity in 1154 aa overlap); Q9L7T3|UVRD|PA5443 mismatch repair protein MUTU (DNA helicase II) from Pseudomonas aeruginosa (728 aa), FASTA scores: opt: 239, E(): 7.3e-06,(23.8% identity in 677 aa overlap) (no similarity in C-terminal part for this one); etc. C-terminal region similar [...]
 
 
0.999
uvrD2
Probable ATP-dependent DNA helicase II UvrD2; DNA-dependent ATPase, stimulated equally by ss- and dsDNA. Has both ATPase and helicase activities, and translocates along ssDNA displacing bound streptavidin. Its essentiality for growth does not depend on its helicase activity.
 
 
 
0.959
uvrD1
Probable ATP-dependent DNA helicase II UvrD1; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. A minimal tail of 18 nt is required for activity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair, as well as in nitrosative and oxidative stress response and possibly in persistence in the host. Inhibits RecA-mediated DNA strand exchange; this does not require ATPase activity. When combined with UvrA greatly inhibits RecA- mediated DNA strand exchange; Belongs to the helicase family. UvrD sub [...]
 
 
 
0.951
Rv1157c
Rv1157c, (MTCI65.24c), len: 371 aa. Conserved Ala-,Pro-rich protein, similar to other proline rich proteins and extensins e.g. GBU04267|g451543 sea-island cotton proline-rich protein of cotton fiber (214 aa), FASTA scores: opt: 305, E(): 3.9e-05, (35.7% identity in 182 aa overlap). Has hydrophobic stretch at N-terminus suggestive of secretion signal. First start taken. A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
 
   
 0.885
Rv3200c
Rv3200c, (MTV014.44c), len: 355 aa. Possible transmembrane cation transporter, similar to many transmembrane proteins and putative potassium channels e.g. Q9XA52|SCGD3.27C putative membrane protein from Streptomyces coelicolor (365 aa), FASTA scores: opt: 1022,E(): 2.6e-53, (49.85% identity in 325 aa overlap); Q9RRZ3|DR2336 putative potassium channel from Deinococcus radiodurans (320 aa), FASTA scores: opt: 436, E(): 1e-18,(30.9% identity in 304 aa overlap); O28600|AF1673 putative potassium channel from Archaeoglobus fulgidus (314 aa),FASTA scores: opt: 363, E(): 2.1e-14, (27.2% identi [...]
  
  
 0.812
recA
RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
 
 
 0.805
polA
Probable DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.801
Rv2090
Probable 5'-3' exonuclease; 5'-3' exonuclease acting preferentially on double-stranded DNA.
 
 
 
 0.769
dnaB
Probable replicative DNA helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity; Belongs to the helicase family. DnaB subfamily.
  
 
 0.753
nudC
NADH pyrophosphatase; Rv3199c, (MTV014.43)c, len: 313 aa. Probable nudC,NADH pyrophosphatase, similar in particular to Q9CXN4|4933433B15RIK from Mus musculus (Mouse) (356 aa),FASTA scores: opt: 493, E(): 7.4e-24, (39.65% identity in 232 aa overlap); Q9ABG1|CC0266 mutt/NUDIX family protein from Caulobacter crescentus (313 aa), FASTA scores: opt: 479, E(): 5.1e-23, (38.3% identity in 222 aa overlap); O86062|NUDC_PSEAE|NUDC|PA1823 NADH pyrophosphatase from Pseudomonas aeruginosa (278 aa), FASTA scores: opt: 371,2 E(): 3e-16, (43.15% identity in 153 aa overlap); Q9RV62|NUDC_DEIRA|NUDC|DR11 [...]
       0.746
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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