Rv3212, (MTCY07D11.14c), len: 407 aa. Conserved ala-, val-rich protein, equivalent to Q9CCH4|ML0810 putative membrane protein from Mycobacterium leprae (407 aa), FASTA scores: opt: 2158, E(): 5.3e-119, (79.85% identity in 407 aa overlap). Weak similarity to several eukaryotic transcription factors e.g. P08393|ICP0_HSV11|ICP0|IE110 trans-acting transcriptional protein from Herpes simplex virus (type 1 / strain 17) (775 aa), FASTA scores: opt: 115, E(): 2, (26.9% identity in 334 aa overlap). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004). Predi [...]

PE-PGRS family protein PE_PGRS7; Rv0578c, (MTV039.16c), len: 1306 aa. PE_PGRS7,Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see citation below), highly similar to many other PGRS proteins e.g. MTCY493.04|Z95844 from Mycobacterium tuberculosis (1329 aa), FASTA scores: opt: 3994, E(): 0, (54.6% identity in 1375 aa overlap). Contains two PS00583 pfkB family of carbohydrate kinases signatures possibly fortuitously.

Probable isochorismate synthase EntC (isochorismate hydroxymutase) (enterochelin biosynthesis); Catalyzes the conversion of chorismate to isochorismate.

Possible phosphoglycerate mutase Gpm2 (phosphoglyceromutase) (PGAM) (BPG-dependent PGAM); Phosphatase with a broad specificity. Can dephosphorylate a variety of substrates including phosphorylated sugars like fructose-6- phosphate (F6P). Is able to function in vivo as a fructose-1,6-bisphosphatase (FBPase) and to maintain gluconeogenesis when the classical FBPase GlpX is absent. Shows negligible phosphoglycerate mutase activity. Has no phosphatase activity against 3-phosphoglycerate, 2,3- bisphosphoglycerate, or hydrophobic substrates such as alpha-napthyl phosphate.

PE-PGRS family protein PE_PGRS4; Rv0279c, (MTV035.07c), len: 837 aa. PE_PGRS4, Member of the Mycobacterium tuberculosis PE family, PGRS subfamily of gly-rich proteins (see Brennan and Delogu, 2002),similar to many e.g. Z95890|MTCY28_25|Rv0278c from Mycobacterium tuberculosis (914 aa), FASTA scores: opt: 2677, E(): 0, (64.5% identity in 926 aa overlap).

Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). Binds its own promoter.

Hypothetical protein; Rv2647, (MTCY441.17), len: 122 aa (questionable ORF). Hypothetical protein, probably corresponds to conserved DNA sequence also found in MTCY336.29c and Rv1574|MTCY336.30c|O06616 hypothetical 11.4 KDA protein from Mycobacterium tuberculosis (103 aa), FASTA scores: opt: 170, E(): 0.0002, (69.05% identity in 42 aa overlap). Shows weak similarity with Q9EUM1|RESB resolvase protein homolog from Corynebacterium glutamicum (Brevibacterium flavum) (343 aa), FASTA scores: opt: 112, E(): 2.9, (31.05% identity in 87 aa overlap).

Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH.

Rv2813, (MTCY16B7.30c), len: 270 aa. Conserved hypothetical protein, similar to various proteins (notably secreted proteins) e.g. Q9ZFL2 hypothetical 30.4 KDA protein from Bacillus stearothermophilus (266 aa), FASTA scores: opt: 518, E(): 1.4e-26, (33.85% identity in 266 aa overlap); P45754|GSPA_AERHY|EXEA general secretion pathway protein from Aeromonas hydrophila (547 aa), FASTA scores: opt: 386, E(): 1.1e-17, (32.05% identity in 265 aa overlap); Q9KPC7|VC2445 general secretion pathway protein A from Vibrio cholerae (529 aa), FASTA scores: opt: 366, E(): 2.2e-16, (31.1% identity in 2 [...]