node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3222c | Rv3224 | Rv3222c | Rv3224 | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | 0.456 |
Rv3222c | Rv3224B | Rv3222c | Rv3224B | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | 0.418 |
Rv3222c | TB7.3 | Rv3222c | Rv3221c | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | 0.461 |
Rv3222c | rshA | Rv3222c | Rv3221A | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | Anti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress. | 0.978 |
Rv3222c | sigH | Rv3222c | Rv3223c | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and ind [...] | 0.970 |
Rv3224 | Rv3222c | Rv3224 | Rv3222c | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | 0.456 |
Rv3224 | Rv3224B | Rv3224 | Rv3224B | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | 0.886 |
Rv3224 | TB7.3 | Rv3224 | Rv3221c | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | 0.609 |
Rv3224 | rshA | Rv3224 | Rv3221A | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | Anti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress. | 0.720 |
Rv3224 | sigH | Rv3224 | Rv3223c | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and ind [...] | 0.722 |
Rv3224B | Rv3222c | Rv3224B | Rv3222c | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | 0.418 |
Rv3224B | Rv3224 | Rv3224B | Rv3224 | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | 0.886 |
Rv3224B | rshA | Rv3224B | Rv3221A | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | Anti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress. | 0.719 |
Rv3224B | sigH | Rv3224B | Rv3223c | Rv3224B, len: 72 aa. Conserved hypothetical protein (possibly gene fragment), similar to C-terminal part of ML0799|AL583919_131 conserved hypothetical protein from Mycobacterium leprae (135 aa), FASTA scores: opt: 229, E(): 2e-09, (60.00% identity in 70 aa overlap). Note that downstream ORF Rv3224A is similar to N-terminus of ML0799. There appears to be no frameshift as sequence is identical in strain CDC1551 and in Mycobacterium bovis. Predicted to be an outer membrane protein (See Song et al., 2008). | Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and ind [...] | 0.718 |
TB7.3 | Rv3222c | Rv3221c | Rv3222c | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | Rv3222c, (MTCY07D11.04), len: 183 aa. Hypothetical protein, with some similarity to Q9SZD2|F19B15.50|AT4G29020 glycine-rich protein like from Arabidopsis thaliana (Mouse-ear cress) (158 aa), FASTA scores: opt: 131, E(): 0.77, (33.35% identity in 126 aa overlap); Q9S222|SCI51.18 putative transcriptional regulator from Streptomyces coelicolor (548 aa), FASTA scores: opt: 133, E(): 1.6,(36.25% identity in 149 aa overlap); etc. Also some similarity to other hypothetical Mycobacterium tuberculosis proteins e.g. O06292|Rv0341|MTCY13E10.01 (479 aa), FASTA scores: opt: 141, E(): 0.5, (31.2% id [...] | 0.461 |
TB7.3 | Rv3224 | Rv3221c | Rv3224 | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | Rv3224, (MTCY07D11.02c), len: 282 aa. Probable iron-regulated oxidoreductase, possible short-chain dehydrogenase/reductase, highly similar to BAB49551|MLL2413 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (288 aa), FASTA scores: opt: 1053, E(): 6.4e-59,(57.95% identity in 276 aa overlap); Q9AB34|CC0400 short chain dehydrogenase family protein from Caulobacter crescentus (285 aa), FASTA scores: opt: 1051, E(): 8.5e-59,(55.9% identity in 281 aa overlap); and Q9VB10|CG5590 hypothetical protein (similar to the short-chain dehydrogenases/reductases (SDR) family) from Drosoph [...] | 0.609 |
TB7.3 | rshA | Rv3221c | Rv3221A | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | Anti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress. | 0.728 |
TB7.3 | sigH | Rv3221c | Rv3223c | Biotinylated protein TB7.3; Rv3221c, (MTCY07D11.05), len: 71 aa. TB7.3,Biotinylated protein (see citations below), equivalent (appears to have one additional residue) to Q9CCH9|ML0802|BTB7_MYCLE biotinylated protein TB7.3 homolog from Mycobacterium leprae (70 aa), FASTA scores: opt: 367,E(): 4e-18, (90.0% identity in 70 aa overlap); Q9XCD6|BTB7_MYCSM biotinylated protein TB7.3 homolog from Mycobacterium smegmatis (70 aa), FASTA scores: opt: 341,E(): 2.1e-16, (84.05% identity in 69 aa overlap). Similar to C-terminal part of various proteins e.g. Q9HPP8|ACC|VNG1532G biotin carboxylase fr [...] | Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and ind [...] | 0.743 |
moeB1 | rshA | Rv3206c | Rv3221A | Probable adenylyltransferase/sulfurtransferase MoeZ; Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl-adenylate (CysO- COOAMP), followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. | Anti-sigma factor RshA; An redox-regulated anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigH. ECF sigma factors are held in an inactive form by a cognate anti-sigma factor. RshA and some peptides derived from it inhibit the sigma factor activity of SigH. Probably releases SigH during oxidative stress. | 0.704 |
moeB1 | sigH | Rv3206c | Rv3223c | Probable adenylyltransferase/sulfurtransferase MoeZ; Catalyzes the conversion of the sulfur carrier protein CysO to CysO-thiocarboxylate. The reaction is thought to proceed in two steps: first, ATP-dependent activation of CysO as acyl-adenylate (CysO- COOAMP), followed by sulfur transfer to give CysO-thiocarboxylate (CysO-COSH) (Probable). The sulfur source is unknown. | Alternative RNA polymerase sigma-E factor (sigma-24) SigH (RPOE); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor (RshA) until released. This sigma factor is involved in heat shock and oxidative stress responses; it positively regulates the expression of itself, sigE, sigB and a number of transcriptional regulators as well as other effectors of heat and oxidative stress, leading to direct and ind [...] | 0.532 |