node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3230c | Rv3231c | Rv3230c | Rv3231c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Conserved protein; Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap). | 0.952 |
Rv3230c | desA1 | Rv3230c | Rv0824c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.931 |
Rv3230c | desA2 | Rv3230c | Rv1094 | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.930 |
Rv3230c | desA3 | Rv3230c | Rv3229c | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.999 |
Rv3231c | Rv3230c | Rv3231c | Rv3230c | Conserved protein; Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap). | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.952 |
Rv3231c | desA3 | Rv3231c | Rv3229c | Conserved protein; Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap). | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.710 |
desA1 | Rv3230c | Rv0824c | Rv3230c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.931 |
desA1 | desA2 | Rv0824c | Rv1094 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.989 |
desA1 | desA3 | Rv0824c | Rv3229c | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.974 |
desA1 | erg3 | Rv0824c | Rv1814 | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | 0.439 |
desA2 | Rv3230c | Rv1094 | Rv3230c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.930 |
desA2 | desA1 | Rv1094 | Rv0824c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.989 |
desA2 | desA3 | Rv1094 | Rv3229c | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | 0.987 |
desA2 | erg3 | Rv1094 | Rv1814 | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | 0.436 |
desA3 | Rv3230c | Rv3229c | Rv3230c | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Hypothetical oxidoreductase; Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Is the electron transfer partner for the stearoyl-CoA 9- desaturase DesA3. Catalyzes electron transfer reaction between NADPH and the diiron center of DesA3. Cannot use NADH. | 0.999 |
desA3 | Rv3231c | Rv3229c | Rv3231c | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Conserved protein; Rv3231c, (MTCY20B11.06c), len: 169 aa. Conserved protein, similar to Q9KYX9|SCE33.03c hypothetical 17.4 KDA protein from Streptomyces coelicolor (167 aa), FASTA scores: opt: 415, E(): 6.6e-19, (49.1% identity in 171 aa overlap). | 0.710 |
desA3 | desA1 | Rv3229c | Rv0824c | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Putative acyl-[acyl-carrier-protein] desaturase DesA1; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.974 |
desA3 | desA2 | Rv3229c | Rv1094 | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Putative acyl-[acyl-carrier-protein] desaturase DesA2; May be a desaturase involved in mycobacterial fatty acid biosynthesis. | 0.987 |
desA3 | erg3 | Rv3229c | Rv1814 | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | 0.578 |
desA3 | fabG2 | Rv3229c | Rv1350 | Possible linoleoyl-CoA desaturase (delta(6)-desaturase); Is likely involved in the aerobic desaturation system responsible for the synthesis of oleic acid from stearoyl-CoA; oleic acid is a precursor of mycobacterial membrane phospholipids and triglycerides. Catalyzes the conversion of stearoyl-CoA to oleoyl-CoA by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Requires the electron transfer partner Rv3230c to pass two electrons from NADPH to its active site diiron center. Is also able to catalyze the 9-desaturation of palmitoyl-CoA to palmitoleoyl-CoA. | Uncharacterized oxidoreductase Rv1350; Rv1350, (MTCY02B10.14), len: 247 aa. Probable fabG2,3-oxoacyl-[acyl-carrier protein] reductase, highly similar to many e.g. NP_350157.1|NC_003030 3-ketoacyl-acyl carrier protein reductase from Clostridium acetobutylicum (249 aa); NP_229523.1|NC_000853 3-oxoacyl-(acyl carrier protein) reductase from Thermotoga maritima (246 aa); AAC44307.1|U59433 3-ketoacyl-acyl carrier protein reductase from Bacillus subtilis (246 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. Belongs to the short-chain dehydrogenases/reductases [...] | 0.560 |