STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
latRv3290c, (MTCY71.30), len: 449 aa. Probable lat,lysine-epsilon aminotransferase, similar to Q05174|LAT_NOCLA from Nocardia lactamdurans (450 aa), FASTA scores: opt: 1702, E(): 1.1e-99, (60.35% identity in 439 aa overlap); and Q01767|Q53823|LAT_STRCL from Streptomyces clavuligerus (457 aa), FASTA scores: opt: 1676, E(): 4.9e-98, (60.15% identity in 434 aa overlap). Also some similarity to 4-aminobutyrate aminotransferase proteins (gamma-amino-N-butyrate transaminases). Belongs to class-III of pyridoxal-phosphate-dependent aminotransferases. Cofactor: pyridoxal phosphate. (449 aa)    
Predicted Functional Partners:
lrpA
Rv3291c, (MTCY71.31c), len: 150 aa. Probable lrpA,transcriptional regulator Lrp/AsnC-family, similar to other regulatory proteins e.g. Q9RKY4|SC6D7.14 from Streptomyces coelicolor (165 aa), FASTA scores: opt: 503, E(): 9.1e-26,(50.35% identity in 143 aa overlap); Q9KYP0|SCD69.13 from Streptomyces coelicolor (167 aa), FASTA scores: opt: 310,E(): 2.7e-13, (37.2% identity in 129 aa overlap); BAB50701|MLL3910 from Rhizobium loti (Mesorhizobium loti) (152 aa), FASTA scores: opt: 282, E(): 1.6e-11, (39.55% identity in 129 aa overlap); O87635|LRP_KLEAE from Klebsiella aerogenes (163 aa), FAST [...]
 
  
 0.982
Rv3289c
Rv3289c, (MTCY71.29c), len: 125 aa. Possible transmembrane protein, showing slight similarity to other membrane proteins or glycoproteins.
  
    0.975
usfY
Putative protein UsfY; Rv3288c, (MTCY71.28c), len: 137 aa. UsfY, putative protein (see citation below). Has no significant homologues. May not be contranscribed with the usfX and sigF proteins.
  
    0.945
Rv1152
Rv1152, (MTCI65.19), len: 121 aa (Start uncertain). Probable transcriptional regulatory protein, some similarity to others e.g. YHCF_BACSU hypothetical transcriptional regulator (121 aa), FASTA scores: opt: 187,E(): 1.9e-06, (34.9% identity in 106 aa overlap). Helix turn helix motif from aa 42-63 (+3.10 SD).
   
  
 0.923
pcd
Rv3293, (MTCY71.33), len: 494 aa. Probable pcd,piperideine-6-carboxylic acid dehydrogenase, highly similar to others e.g. O85725|PCD semialdehyde dehydrogenase from Streptomyces clavuligerus (512 aa), FASTA scores: opt: 2214, E(): 6.7e-121, (68.75% identity in 496 aa overlap) (see Alexander & Jensen 1998); Q9I4U7|PA1027 probable aldehyde dehydrogenase from Pseudomonas aeruginosa (529 aa), FASTA scores: opt: 1984, E(): 1.4e-107, (64.5% identity in 493 aa overlap); BAB49892|MLL2867 aldehyde dehydrogenase from Rhizobium loti (Mesorhizobium loti) (504 aa), FASTA scores: opt: 1964, E(): 2e- [...]
 
 0.853
hsp
Rv0251c, (MTV034.17c), len: 159 aa. Hsp (alternate gene name: hsp20, hrpA, acr2), heat-stress-induced ribosome-binding protein A (see citations below). Highly similar to AAD39038.1|AF072875_1|AF072875 putative HSP20 from Mycobacterium smegmatis (145 aa), FASTA scores: opt: 479, E(): 2.3e-24, (59.9% identity in 157 aa overlap); and similar to many bacterial and eukaryotic hsp proteins e.g. P12811|HS2C_CHLRE chloroplast heat shock 22KD protein from chlamydomonas reinhardtii (157 aa), FASTA scores: opt: 184,E(): 1.2e-05, (32.4% identity in 142 aa overlap). Also similar to PCC6803 Spore pr [...]
  
  
 0.663
Rv3213c
Rv3213c, (MTCY07D11.13), len: 266 aa. Possible soj/parA-related protein, very similar in particular to Soj/ParA proteins (and relatives) from Bacillus subtilis that inhibit the initiation of sporulation by preventing phosphorylation of Spo0A (see Quisel & Grossman 2000) e.g. Q9S228|SCI51.12c from Streptomyces coelicolor (340 aa),FASTA scores: opt: 746, E(): 1.6e-40, (48.2% identity in 249 aa overlap); Q9HT11|SOJ|PA5563 from Pseudomonas aeruginosa (262 aa), FASTA scores: opt: 649, E(): 2.1e-34,(42.2% identity in 256 aa overlap); Q9PB62|XF2282 from Xylella fastidiosa (264 aa), FASTA scor [...]
   
  
 0.654
Rv3292
Rv3292, (MTCY71.32), len: 415 aa. Conserved hypothetical protein, similar to P76097|YDCJ_ECOLI|B1423 hypothetical 51.0 KDA protein from Escherichia coli strain K12 (447 aa), FASTA scores: opt: 747, E(): 5.6e-39, (38.55% identity in 449 aa overlap); BAB35451|ECS2028 hypothetical 51.0 KDA protein from Escherichia coli strain O157:H7 (447 aa), FASTA scores: opt: 744, E(): 8.6e-39, (38.3% identity in 449 aa overlap); AAG56352|Z2297 protein from Escherichia coli O157:H7 EDL933 (212 aa), FASTA scores: opt: 454, E(): 4.6e-21, (41.75% identity in 206 aa overlap); and similar in part with Q4966 [...]
 
  
 0.648
Rv2517c
Unknown protein; Rv2517c, (MTV009.02c), len: 83 aa. Unknown protein. Equivalent to AAK46899 from Mycobacterium tuberculosis strain CDC1551 (97 aa) but shorter 14 aa.
   
  
 0.634
sigI
Possible alternative RNA polymerase sigma factor SigI; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Extracytoplasmic function (ECF) sigma factors are held in an inactive form by a cognate anti-sigma factor until released, although no anti-sigma factor is known for this protein (By similarity).
   
  
 0.609
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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