| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PE26 | phyA | Rv2519 | Rv3397c | Rv2519, (MTV009.04), len: 492 aa. PE26, Member of the M. tuberculosis PE family (see citation below), highly similar to many e.g. Q50630|YP91_MYCTU|Rv2591|MT2668.1|MTCY227.10c (543 aa),FASTA scores: opt: 848, E(): 3e-30, (39.55% identity in 445 aa overlap). | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.852 |
| Rv3399 | guaA | Rv3399 | Rv3396c | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.501 |
| Rv3399 | idsA1 | Rv3399 | Rv3398c | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | (2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. Belongs to the FPP/GGPP synthase family. | 0.789 |
| Rv3399 | phyA | Rv3399 | Rv3397c | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.880 |
| dinF | gap | Rv2836c | Rv1436 | Rv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly s [...] | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | 0.729 |
| dinF | phyA | Rv2836c | Rv3397c | Rv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly s [...] | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.734 |
| erg3 | idi | Rv1814 | Rv1745c | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | 0.498 |
| erg3 | phyA | Rv1814 | Rv3397c | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.737 |
| gap | dinF | Rv1436 | Rv2836c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Rv2836c, (MTCY16B7.06), len: 439 aa. Possible dinF,DNA-damage-inducible protein F, integral membrane protein,similar to others e.g. BAB38450|ECS5027|AAG59243 from Escherichia coli strain O157:H7 (459 aa), FASTA scores: opt: 501, E(): 2.7e-21, (29.55% identity in 443 aa overlap); P28303|DINF_ECOLI|B4044 from Escherichia coli strain K12 (459 aa), FASTA scores: opt: 491, E(): 1e-20,(29.35% identity in 443 aa overlap); Q98B90|MLR5680 from Rhizobium loti (Mesorhizobium loti) (471 aa), FASTA scores: opt: 466, E(): 2.7e-19, (30.7% identity in 433 aa overlap); etc. But also similar or highly s [...] | 0.729 |
| gap | guaA | Rv1436 | Rv3396c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | 0.747 |
| gap | phyA | Rv1436 | Rv3397c | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.772 |
| guaA | Rv3399 | Rv3396c | Rv3399 | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Possible S-adenosylmethionine-dependent methyltransferase; Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity. | 0.501 |
| guaA | gap | Rv3396c | Rv1436 | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Probable glyceraldehyde 3-phosphate dehydrogenase Gap (GAPDH); Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-ph [...] | 0.747 |
| guaA | idsA1 | Rv3396c | Rv3398c | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | (2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. Belongs to the FPP/GGPP synthase family. | 0.779 |
| guaA | phyA | Rv3396c | Rv3397c | Probable GMP synthase [glutamine-hydrolyzing] GuaA (glutamine amidotransferase) (GMP synthetase); Catalyzes the synthesis of GMP from XMP. | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.791 |
| idi | erg3 | Rv1745c | Rv1814 | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Rv1814, (MTCY1A11.29c), len: 300 aa. Erg3,transmembrane C-5 sterol desaturase (see *), weak similarity to several e.g. ERG3_YEAST|P32353 c-5 sterol desaturase (365 aa), FASTA scores: opt: 154, E(): 0.0011,(22.9% identity in 288 aa overlap). Belongs to the sterol desaturase family. [* Note: work of Jackson, C.J., Lamb,D.C., Kelly, D.E., Kelly, S.L., Characterization of a sterol delta 5,6-desaturase homolog in Mycobacterium bovis (BCG). Submitted (jun-2000) to the EMBL/GenBank/DDBJ databases]. | 0.498 |
| idi | idsA1 | Rv1745c | Rv3398c | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | (2E,6E)-farnesyl diphosphate synthase; Catalyzes the condensation of isopentenyl pyrophosphate (IPP) with geranyl diphosphate (GPP) to yield (2E,6E)-farnesyl diphosphate (E,E-FPP). May be used for squalene and possibly sterol biosynthesis. Belongs to the FPP/GGPP synthase family. | 0.941 |
| idi | idsA2 | Rv1745c | Rv2173 | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Rv2173, (MTV021.06), len: 352 aa. Probable idsA2,geranylgeranyl pyrophosphate synthase, similar to many e.g. Q54193 geranylgeranyl pyrophosphate synthase from Streptomyces griseus (425 aa). Contains PS00723 and PS00444Polyprenyl synthetases signature 1 and 2. FASTA scores: sptr|Q54193|Q54193 geranylgeranyl pyrophosphate synthase (425 aa) opt: 744, E(): 0; 39.2% identity in 352 aa overlap. | 0.974 |
| idi | idsB | Rv1745c | Rv3383c | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Rv3383c, (MTV004.41c), len: 350 aa. Possible idsB,polyprenyl transferase (polyprenyl diphosphate synthase), similar to many prenyltransferases involved in lipid biosynthesis e.g. Q9RGW1|GTR geranyl transferase from Streptomyces coelicolor (386 aa), FASTA scores: opt: 908,E(): 3.7e-50, (48.8/% identity in 334 aa overlap); Q9KWG0|GGDPS geranyl geranyl diphosphate synthase from Kitasatospora griseola (Streptomyces griseolosporeus) (348 aa), FASTA scores: opt: 801, E(): 2e-43, (41.5% identity in 347 aa overlap); Q9X7V8|SC6A5.12 putative polyprenyl synthetase from Streptomyces coelicolor (3 [...] | 0.918 |
| idi | phyA | Rv1745c | Rv3397c | Isopentenyl-diphosphate Delta-isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). | Probable phytoene synthase PhyA; Involved in the biosynthesis of carotenoids. Catalyzes the condensation of two molecules of geranylgeranyl diphosphate (GGPP) to give prephytoene diphosphate (PPPP) and the subsequent rearrangement of the cyclopropylcarbinyl intermediate to yield phytoene (By similarity). Belongs to the phytoene/squalene synthase family. | 0.717 |
