STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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choDCholesterol oxidase ChoD (cholesterol-O2 oxidoreductase); Catalyzes the oxidation and isomerization of cholesterol to cholestenone (4-cholesten-3-one), which is an initial step in the cholesterol degradation process. Required for virulence. Belongs to the GMC oxidoreductase family. Highly divergent. (578 aa)    
Predicted Functional Partners:
Rv1106c
3-beta-hydroxysteroid dehydrogenase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidation and isomerization of cholesterol, pregnenolone, and dehydroepiandrosterone (DHEA) into cholest-4-en-3-one, progesterone, and androsterone, respectively.
  
 
 0.993
cyp142
Probable cytochrome P450 monooxygenase 142 Cyp142; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25R)-26-hydroxycholest-4- en-3-one (alcohol), (25R)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25R)-3-oxocholest-4-en-26-oate. In vitro, Cyp142 catalyzes with equal preference the oxidation of both (25R)- and (25S)-26- hydroxycholest-4-en-3-one diastereomers to the corresponding carboxy [...]
     
 0.958
cyp125
Probable cytochrome P450 125 Cyp125; Involved in the utilization of cholesterol as the sole carbon and energy source by degrading the side chain during infection. Primarily catalyzes the sequential oxidation of the terminal methyl of cholest-4-en-3-one into (25S)-26- hydroxycholest-4-en-3-one (alcohol), (25S)-26-oxocholest-4-en-3-one (aldehyde), to finally yield the carboxylic acid (25S)-3-oxocholest-4- en-26-oate. Also able to sequentially oxidize cholesterol itself, not only cholest-4-en- 3-one. Belongs to the cytochrome P450 family.
     
 0.933
guaB2
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Does not catalyze the reverse reaction, i.e. the conversion of XMP to IMP. Appears to be essential for the optimal growth of M.tuberculosis. Belongs to the IMPDH/GMPR family.
  
  
 0.786
kstD
Probable dehydrogenase; Catalyzes the elimination of the C-1 and C-2 hydrogen atoms of the A-ring from the polycyclic ring structure of 3-ketosteroids. Is also involved in the formation of 3-keto-1,4-diene-steroid from 3-keto- 4-ene-steroid.
  
  
 0.712
hsaC
3,4-DHSA dioxygenase; Catalyzes the meta-cleavage of 3,4-dihydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) to produce 4,5- 9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oic acid (4,9-DSHA).
  
  
 0.706
guaB3
Uncharacterized oxidoreductase Rv3410c; Has no inosine-5'-monophosphate dehydrogenase activity. Belongs to the IMPDH/GMPR family.
     
 0.691
mce4A
Mce-family protein Mce4A; Rv3499c, (MTV023.06c), len: 400 aa. Mce4A; belongs to 24-membered Mycobacterium tuberculosis Mce protein family (see citations below), highly similar to Mycobacterium tuberculosis proteins P72013|MCE1|Rv0169|MTCI28.09|mce1A (454 aa); O07789|MCE2|Rv0589|MTCY19H5.33c|mce2A (404 aa); and O53967|MCE3|Rv1966|MTV051.04|mce3A (425 aa). Also similar to others e.g. Q9F356|SC8A2.07c putative secreted protein from Streptomyces coelicolor (418 aa), FASTA scores: opt: 619, E(): 7.8e-30, (32.4% identity in 352 aa overlap); Q9S4U5|MCE1 mycobacterial cell entry protein from M [...]
      
 0.673
Rv1691
Rv1691, MTCI125.13, len: 250 aa. Conserved hypothetical protein, similar to Q9S210|SCI51.30C|AL109848 Hypothetical protein from Streptomyces coelicolor (210 aa),FASTA score: opt: 556, E(): 6.4e-27, (50.6% identity in 180 aa overlap).
    
 0.604
stf3
Conserved hypothetical protein; Required for the sulfation of S881. S881 is a sulfated menaquinone, which is localized in the outer envelope of M.tuberculosis and negatively regulates its virulence. 3'-phosphoadenosine-5'- phosphosulfate (PAPS) is the sulfate donor. Belongs to the Stf3 family.
    
 0.604
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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