node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Rv3256c | Rv3421c | Rv3256c | Rv3421c | Conserved protein; Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved protein, equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). A core mycobacterial ge [...] | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | 0.686 |
Rv3256c | cobN | Rv3256c | Rv2062c | Conserved protein; Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved protein, equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). A core mycobacterial ge [...] | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.746 |
Rv3256c | murC | Rv3256c | Rv2152c | Conserved protein; Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved protein, equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). A core mycobacterial ge [...] | Probable UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family. | 0.764 |
Rv3421c | Rv3256c | Rv3421c | Rv3256c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Conserved protein; Rv3256c, (MTV015.01c-MTCY20B11.31c), len: 346 aa. Conserved protein, equivalent to Q9CCJ6|ML0764 hypothetical protein from Mycobacterium leprae (365 aa), FASTA scores: opt: 1574, E(): 1.4e-82, (75.35% identity in 365 aa overlap). Also similar to other hypothetical bacterial proteins e.g. Q9KZL8|SCE34.07c from Streptomyces coelicolor (375 aa), FASTA scores: opt: 171, E(): 0.012, (31.1% identity in 376 aa overlap); P55709|Y4YA_RHISN from Rhizobium sp. strain NGR234 (457 aa), FASTA scores: opt: 140, E(): 0.84, (28.75% identity in 233 aa overlap). A core mycobacterial ge [...] | 0.686 |
Rv3421c | TB22.2 | Rv3421c | Rv3036c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Probable conserved secreted protein TB22.2; Hydrolyzes ester substrates carbon chain lengths ranging from C2 to C14. In vitro, acetate (C2), butyrate (C4) and caprylate (C6) are hydrolyzed with high efficiency. Has lower activity against laurate (C12), myristate (C14) and caproate (C8), and weak activity against palmitate (C16). | 0.563 |
Rv3421c | alr | Rv3421c | Rv3423c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | 0.955 |
Rv3421c | birA | Rv3421c | Rv3279c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | BirA protein; Rv3279c, (MTCY71.19c), len: 266 aa. Possible birA,bifunctional protein: biotin operon repressor and biotin--[acetyl-CoA-carboxylase] synthetase, equivalent to Q9CCL3|BIRA|ML0732 biotin APO-protein ligase from Mycobacterium leprae (274 aa), FASTA scores: opt: 1189,E(): 2.3e-66, (71.2% identity in 271 aa overlap). But as it lacks a BirA h-t-h domain at N-terminus, may simply be biotin apo-protein ligase. Also similar to others e.g. Q9CNX6|BIRA|PM0296 from Pasteurella multocida (312 aa),FASTA scores: opt: 347, E(): 2.7e-14, (32.95% identity in 270 aa overlap); Q9HWC0|BIRA|PA [...] | 0.617 |
Rv3421c | cobN | Rv3421c | Rv2062c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Rv2062c, (MTCY49.01c, MTV019.03), len: 1194 aa. cobN, cobalamin biosynthesis protein, similar to many. | 0.672 |
Rv3421c | gcp | Rv3421c | Rv3419c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. | 0.999 |
Rv3421c | groES | Rv3421c | Rv3418c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.761 |
Rv3421c | murC | Rv3421c | Rv2152c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Probable UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family. | 0.704 |
Rv3421c | rimI | Rv3421c | Rv3420c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | N-alpha-acetyltransferase RimI; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues. Able to mediate acetylation of a wide variety of N-terminal residues, with preference for hydrophobic N- termini. Acetylates GroS/GroES and GroEL1. Able to acetylate the ribosomal protein S18, but it is unclear whether it acetylates its N- terminal alanine residue; Belongs to the acetyltransferase family. RimI subfamily. | 0.996 |
Rv3421c | tsaE | Rv3421c | Rv3422c | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). | 0.999 |
TB22.2 | Rv3421c | Rv3036c | Rv3421c | Probable conserved secreted protein TB22.2; Hydrolyzes ester substrates carbon chain lengths ranging from C2 to C14. In vitro, acetate (C2), butyrate (C4) and caprylate (C6) are hydrolyzed with high efficiency. Has lower activity against laurate (C12), myristate (C14) and caproate (C8), and weak activity against palmitate (C16). | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | 0.563 |
TB22.2 | gcp | Rv3036c | Rv3419c | Probable conserved secreted protein TB22.2; Hydrolyzes ester substrates carbon chain lengths ranging from C2 to C14. In vitro, acetate (C2), butyrate (C4) and caprylate (C6) are hydrolyzed with high efficiency. Has lower activity against laurate (C12), myristate (C14) and caproate (C8), and weak activity against palmitate (C16). | Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. | 0.495 |
alr | Rv3421c | Rv3423c | Rv3421c | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | Rv3421c, (MTCY78.08), len: 211 aa. Conserved hypothetical protein, equivalent to Q49857|YY21_MYCLE|ML0378|B229_C1_170 hypothetical 38.0 KDA protein from Mycobacterium leprae (359 aa), FASTA scores: opt: 1000, E(): 1.8e-50, (75.6% identity in 205 aa overlap). Also similar to other hypothetical bacterial proteins e.g. O86791|SC6G4.28 from Streptomyces coelicolor (217 aa), FASTA scores: opt: 453, E(): 3.3e-19, (48.1% identity in 212 aa overlap); Q9AC10|CC0059 (glycoprotease family protein) from Caulobacter crescentus (211 aa), FASTA scores: opt: 248, E(): 2e-07, (34.3% identity in 210 aa [...] | 0.955 |
alr | gcp | Rv3423c | Rv3419c | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | Probable O-sialoglycoprotein endopeptidase Gcp (glycoprotease); Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. | 0.916 |
alr | groES | Rv3423c | Rv3418c | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | 10 kDa chaperonin GroES (protein CPN10) (protein GroES) (BCG-a heat shock protein) (10 kDa antigen); Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter; Belongs to the GroES chaperonin family. | 0.561 |
alr | murC | Rv3423c | Rv2152c | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | Probable UDP-N-acetylmuramate-alanine ligase MurC; Cell wall formation; Belongs to the MurCDEF family. | 0.753 |
alr | rimI | Rv3423c | Rv3420c | Alanine racemase Alr; Catalyzes the interconversion of L-alanine and D-alanine. D- alanine plays a key role in peptidoglycan cross-linking. | N-alpha-acetyltransferase RimI; N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues. Able to mediate acetylation of a wide variety of N-terminal residues, with preference for hydrophobic N- termini. Acetylates GroS/GroES and GroEL1. Able to acetylate the ribosomal protein S18, but it is unclear whether it acetylates its N- terminal alanine residue; Belongs to the acetyltransferase family. RimI subfamily. | 0.928 |