Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
bpoARv3473c, (MTCY13E12.26c), len: 261 aa. Possible bpoA, peroxidase (non-haem peroxidase), similar to various enzymes or hypothetical unknown proteins e.g. O85849 hypothetical 26.2 KDA protein from Sphingomonas aromaticivorans (247 aa), FASTA scores: opt: 684, E(): 4.9e-34, (43.8% identity in 242 aa overlap); AAK45412|MT1155 hydrolase, alpha/beta hydrolase fold family from Mycobacterium tuberculosis strain CDC1551 (311 aa),FASTA scores: opt: 675, E(): 2e-33, (39.45% identity in 256 aa overlap); Q9K3V0|SCD10.27 putative hydrolase from Streptomyces coelicolor (352 aa), FASTA scores: opt: 24 [...] (261 aa)    
Predicted Functional Partners:
pks5
Probable polyketide synthase Pks5; Polyketide synthase likely involved in the biosynthesis of a polymethyl-branched fatty acid (PMB-FA) that might only be produced during host infection. Is required for the full virulence of M.tuberculosis during host infection.
  
 0.578
pks12
Polyketide synthase Pks12; Rv2048c, (MTV018.35c), len: 4151 aa. Pks12,polyketide synthase similar to many. Contains 2x PS00012 Phosphopantetheine attachment site, 2x PS00606 Beta-ketoacyl synthases active site, and PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. Nucleotide position 2297976 in the genome sequence has been corrected, G:A resulting in S3004L.
  
 0.578
ppsC
Phenolpthiocerol synthesis type-I polyketide synthase PpsC; Involved in the elongation of either C22-24 fatty acids by the addition of malonyl-CoA and methylmalonyl-CoA extender units to yield phthiocerol derivatives.
  
 0.578
mas
Rv2940c, (MTCY24G1.09, MTCY19H9.08c), len: 2111 aa. Probable mas, mycocerosic acid synthase membrane associated, multifunctional enzyme (see citations below),almost identical to Q02251|MCAS_MYCBO|mas mycocerosic acid synthase from Mycobacterium bovis (2110 aa), FASTA scores: opt: 13226, E(): 0, (95.8% identity in 2115 aa overlap) (see Mathur & Kolattukudy 1992); and equivalent to Q9CD78|mas|ML0139 putative mycocerosic synthase from Mycobacterium leprae (2116 aa), FASTA scores: opt: 12142,E(): 0, (87.95% identity in 2119 aa overlap); and Q49624|PKS3|MASA|ML1229|B1170_C2_209 probable myc [...]
  
 0.578
pks2
Polyketide synthase Pks2; Catalyzes the synthesis of the hepta- and octamethyl phthioceranic acids and/or hydroxyphthioceranic acids that are the major acyl constituents of sulfolipids.
  
 0.578
Rv2627c
Conserved protein; Rv2627c, (MTCY01A10.05), len: 413 aa. Conserved protein. Some similarity in C-terminal part of O53697|Rv0293c|MTV035.21c hypothetical 44.0 KDA protein from Mycobacterium tuberculosis (400 aa), FASTA scores: opt: 392, E(): 1.9e-17, (31.1% identity in 299 aa overlap). Alternative nucleotide at position 2954439 (T->C; R104G) has been observed. Predicted possible vaccine candidate (See Zvi et al., 2008).
 
  
 0.551
Rv0216
Double hotdog hydratase; Rv0216, (MTCY08D5.11), len: 337 aa. Double hotdog R-specific hydratase of unknown function, shows no activity for crotonyl-CoA, equivalent to Z95398|MLCL622_22 from Mycobacterium leprae (339 aa), FASTA scores: E(): 0, (73.7 identity in 338 aa overlap). Shows structural similarity to six others in Mycobacterium tuberculosis (see Castell et al (2005) below). A core mycobacterial gene; conserved in mycobacterial strains (See Marmiesse et al., 2004).
 
 
  0.550
Rv3474
Possible transposase for insertion element IS6110 (fragment); Rv3474, (MTCY13E12.27), len: 108 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3474 and Rv3475, the sequence UUUUAAAG (directly upstream of Rv3475) maybe responsible for such a frameshifting event (see McAdam et al., 1990). Belongs to the transposase family 8.
  
    0.548
Rv3475
Possible transposase for insertion element IS6110 [second part]; Rv3475, (MTCY13E12.28), len: 328 aa. Probable transposase subunit for IS6110. Identical to many other M. tuberculosis IS6110 transposase subunits. The transposase described here may be made by a frame shifting mechanism during translation that fuses Rv3474 and Rv3475, the sequence UUUUAAAG (directly upstream of Rv3475) maybe responsible for such a frameshifting event (see McAdam et al., 1990). Start changed since first submission (- 18 aa).
       0.546
Rv3672c
Rv3672c, (MTV025.020c), len: 273 aa. Conserved hypothetical protein, equivalent to Q9CB94|ML2299 hypothetical protein from Mycobacterium leprae (266 aa) FASTA scores: opt: 1358, E(): 5.2e-75, (76.4% identity in 267 aa overlap). Also similar to others (generally in C-terminal end) e.g. Q9XA45|SCH17.02c hypothetical 26.5 KDA protein from Streptomyces coelicolor (247 aa) FASTA scores: opt: 524, E(): 1.3e-24, (42.65% identity in 251 aa overlap); Q9AB27|CC0407 mutt/NUDIX family protein from Caulobacter crescentus (216 aa), FASTA scores: opt: 285,E(): 3.2e-10, (36.2% identity in 174 aa overl [...]
  
  
  0.493
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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