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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
panCPantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme); Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. (309 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase PanB; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate.
  
 0.999
coaX
Conserved protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family.
  
 
 0.999
panD
Probable aspartate 1-decarboxylase precursor PanD (aspartate alpha-decarboxylase); Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine; Belongs to the PanD family.
 
 
 0.999
Rv3603c
Rv3603c, (MTCY07H7B.19), len: 303 aa. Conserved hypothetical ala-, leu-rich protein, identical except at N-terminus (really different) to AAK48066|MT3708 chalcone/stilbene synthase family protein from Mycobacterium tuberculosis strain CDC1551 (361 aa) FASTA scores: opt: 1742, E(): 8.3e-95, (100.0% identity in 275 aa overlap). Equivalent to O69525|MLCB2548.02c|ML0229 hypothetical 32.7 KDA protein from Mycobacterium leprae (309 aa), FASTA scores: opt: 947, E(): 2.4e-48, (67.85% identity in 311 aa overlap). Also highly similar to Q9X845|SCE126.02c hypothetical 42.2 KDA protein from Strept [...]
   
 0.997
coaA
Rv1092c, (MTV017.45c), len: 312 aa. Probable coaA,pantothenate kinase, similar to many e.g. P15044|COAA_ECOLI Escherichia coli (316 aa), FASTA scores :opt: 1079, E(): 0,(52.7% identity in 311 aa overlap). Equivalent to AL049491|MLCB1222_17 Mycobacterium leprae (312 aa) (93.6% identity in 312 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Belongs to the pantothenate kinase family.
     
 0.961
dfp
Probable DNA/pantothenate metabolism flavoprotein homolog Dfp; Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'- phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'- phosphopantotheine; In the N-terminal section; belongs to the HFCD (homo- oligomeric flavin containing Cys decarboxylase) superfamily.
 
 
 0.954
Rv2573
Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.948
gadB
Rv3432c, (MTCY77.04c), len: 460 aa. Probable gadB,glutamate decarboxylase, similar to many e.g. P73043|gad|SLL1641 from Synechocystis sp. strain PCC 6803 (467 aa), FASTA scores: opt: 1684, E(): 6.2e-99, (55.35% identity in 457 aa overlap); Q9X8J5|SCE9.23 from Streptomyces coelicolor (475 aa), FASTA scores: opt: 1650,E(): 8.9e-97, (57.4% identity in 446 aa overlap); Q9AQU4|gad from Oryza sativa (Rice) (501 aa), FASTA scores: opt: 1498, E(): 3.7e-87, (51.6% identity in 432 aa overlap); Q07346|DCE_PETHY from Petunia hybrida (Petunia) (500 aa), FASTA scores: opt: 1485, E(): 2.5e-86, (51.15 [...]
  
 
 0.941
cmk
Cytidylate kinase Cmk (CMP kinase) (cytidine monophosphate kinase) (ck); Rv1712, (MTCI125.34), len: 230 aa. cmk, cytidylate kinase, highly similar to many e.g. KCY_ECOLI|P23863 cytidylate kinase from Escherichia coli (227 aa), FASTA scores: opt: 534, E (): 0, (40.3% identity in 221 aa overlap). Contains PS00017 ATP/GTP-binding site motif A (P-loop). Equivalent to Z95117|MLCB1351_2 from Mycobacterium leprae (223 aa) (73.5% identity in 226 aa overlap). Belongs to the cytidylate kinase family,subfamily 1.
 
    0.909
Rv0147
Rv0147, (MTCI5.21), len: 506 aa. Probable aldehyde dehydrogenase (NAD+) dependent, similar to others e.g. DHAP_RAT|P11883 aldehyde dehydrogenase (dimeric NADP-preferring) (452 aa), FASTA scores: opt: 1291, E(): 0,(43.9% identity in 453 aa overlap). Also similar to several Mycobacterium tuberculosis aldehyde dehydrogenases e.g. Rv0768, Rv2858c, etc. Contains PS00687 aldehyde dehydrogenases glutamic acid active site, and PS00070 aldehyde dehydrogenases cysteine active site. Belongs to the aldehyde dehydrogenases family.
     
 0.903
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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