STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dppDRv3663c, (MTV025.011c), len: 548 aa. Probable dppD,dipeptide-transport ATP-binding protein ABC-transporter (see citation below), similar to many ATP-binding proteins e.g. AAK65441|SMA1434 probable ABC transporter ATP-binding protein from Rhizobium meliloti (Sinorhizobium meliloti) plasmid pSymA (550 aa), FASTA scores: opt: 1528, E(): 1e-78, (46.25% identity in 545 aa overlap); O50270|MOAD MOAD protein from Agrobacterium radiobacter (588 aa), FASTA scores: opt: 1354, E(): 6.7e-69, (42.9% identity in 541 aa overlap); Q9KM01|VCA0588 putative peptide ABC transporter ATP-binding protein fro [...] (548 aa)    
Predicted Functional Partners:
dppC
Rv3664c, (MTV025.012c), len: 266 aa. Probable dppC,dipeptide-transport integral membrane protein ABC-transporter (see Braibant et al., 2000), similar to many peptide permeases e.g. Q9F351|SC9E12.04 putative peptide transport system integral membrane from Streptomyces coelicolor (305 aa), FASTA scores: opt: 901,E(): 1.1e-47, (51.15% identity in 262 aa overlap); Q9KFX1|APPC|BH0349 oligopeptide ABC transporter (permease) from Bacillus halodurans (305 aa), FASTA scores: opt: 652,E(): 1.5e-32, (35.55% identity in 270 aa overlap); P94312|DPPC_BACFI dipeptide transport system permease protein [...]
 
 0.999
dppB
Rv3665c, (MTV025.013c), len: 308 aa. Probable dppB,dipeptide-transport integral membrane protein ABC-transporter (see citation below), similar to many peptide permeases e.g. Q9F352|SC9E12.03 putative peptide transport system integral membrane protein from Streptomyces coelicolor (307 aa), FASTA scores: opt: 1145,E(): 1.8e-61, (57.65% identity in 307 aa overlap); Q53191|Y4TP_RHISN probable peptide ABC transporter permease protein Rhizobium sp. strain NGR234 (313 aa), FASTA scores: opt: 653, E(): 5.2e-32, (31.2% identity in 314 aa overlap); P24138|OPPB_BACSU oligopeptide transport system [...]
 
 0.999
oppC
Rv1282c, (MTCY373.01c-MTCY3H3.01), len: 291 aa. Probable oppC, oligopeptide-transport integral membrane protein ABC transporter (see Braibant et al., 2000),similar to other integral membrane proteins e.g. OPPC_ECOLI|P77664 oligopeptide transport system permease from Escherichia coli (302 aa), FASTA scores: E(): 4.6e-33,(40.7% identity in 275 aa overlap); etc. Also similar to Rv3664c|DPPC probable peptide-transport integral membrane protein from Mycobacterium tuberculosis.
 
 0.998
dppA
Rv3666c, (MTV025.014c), len: 541 aa. Probable dppA,dipeptide-binding lipoprotein component of dipeptide transport system (see citation below), similar to many substrate-binding proteins e.g. Q9F353|SC9E12.02 putative peptide transport system secreted peptide-binding protein from Streptomyces coelicolor (544 aa), FASTA scores: opt: 1200, E(): 9e-67, (39.2% identity in 538 aa overlap); P24141|OPPA_BACSU oligopeptide-binding protein from Bacillus subtilis (545 aa), FASTA scores: opt: 523, E(): 7.9e-25, (26.15% identity in 516 aa overlap); P23843|OPPA_ECOLI periplasmic oligopeptide-binding [...]
 
 
 0.998
oppB
Rv1283c, (MTCY373.02c), len: 325 aa. Probable oppB,oligopeptide-transport integral membrane protein ABC transporter (see citation below), similar to other integral membrane proteins e.g. DPPB_ECOLI|P37316 dipeptide transport system permease protein from Escherichia coli (339 aa), FASTA scores: opt: 402, E(): 3.4e-20, (31.0% identity in 345 aa overlap); etc. Also similar to Rv3665c|DppB probable peptide-transport integral membrane protein from Mycobacterium tuberculosis. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp signature.
 
 0.997
oppA
Rv1280c, (MTCY50.02), len: 591 aa. Probable oppA,oligopeptide-binding lipoprotein component of peptide transport system (see citation below), sharing some similarity to other periplasmic solute binding proteins e.g. OPPA_SALTY|P06202 periplasmic oligopeptide-binding protein from Salmonella typhimurium (542 aa), FASTA scores: E(): 5.1e-05, (22.1% identity in 458 aa overlap); etc. Also similar to Rv1166 and Rv2585c from Mycobacterium tuberculosis. Has possible N-terminal signal sequence and prokaryotic lipoprotein lipid attachment site (PS00013). Belongs to the bacterial extracellular so [...]
 
 
 0.989
Rv2585c
Possible conserved lipoprotein; Rv2585c, (MT2662, MTCY227.16), len: 557 aa. Possible conserved lipoprotein precursor, possibly attached to the membrane by a lipid anchor and substrate-binding protein involved in transport, equivalent to Q49646|YP85_MYCLE|ML0489|MLCB1259.07|B1177_C2_197 hypothetical lipoprotein precursor from Mycobacterium leprae (555 aa), FASTA scores: opt: 2812, E(): 9.8e-158,(78.95% identity in 546 aa overlap); and C-terminus highly similar to C-terminus of Q49638|DCIAE|B1177_C1_166 DCIAE protein from Mycobacterium leprae (344 aa), FASTA scores: opt: 1177, E(): 7.4e- [...]
  
 
 0.944
Rv3662c
Rv3662c, (MTV025.010c), len: 256 aa. Conserved hypothetical protein, equivalent to Q9CB99|ML2289 hypothetical protein from Mycobacterium leprae (256 aa) FASTA scores: opt: 1255, E(): 3.3e-69, (78.05% identity in 255 aa overlap). Also similar to Q9X924|SCH5.22c putative oxidoreductase from Streptomyces coelicolor (274 aa), FASTA scores: opt: 289, E(): 1.8e-10, (39.25% identity in 270 aa overlap).
  
  
 0.928
oppD
Rv1281c, (MTCY50.01), len: 612 aa. Probable oppD,oligopeptide-transport ATP-binding protein ABC transporter (see citation below), similar to others e.g. DPPD_BACSU|P26905 dipeptide transport ATP-binding protein from Bacillus subtilis (335 aa), FASTA scores: opt: 983,E(): 0, (48.6% identity in 319 aa overlap); etc. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); 2 x PS00211 ABC transporters family signature. Belongs to the ATP-binding transport protein family (ABC transporters).
 
 
0.917
Rv2325c
Rv2325c, (MTCY3G12.09), len: 282 aa. Conserved hypothetical protein, equivalent to O32970|MLCB22.37c|ML0849 hypothetical protein from Mycobacterium leprae (283 aa), FASTA scores: opt: 1405,E(): 1.8e-78, (77.7% identity in 282 aa overlap). Also some similarity to other proteins e.g. Q9Z9J1|YBAF|BH0166 YBAF protein (BH0166 protein) (hypothetical protein) from Bacillus halodurans (265 aa), FASTA scores: opt: 288, E(): 2.8e-10, (25.8% identity in 264 aa overlap); P70972|YBAF YBAF protein (hypothetical protein) from Bacillus subtilis (265 aa), FASTA scores: opt: 259, E(): 1.5e-08, (25.45% i [...]
  
 
 0.815
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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