Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
vapC48Possible toxin VapC48. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase. Its cognate antitoxin is VapB48.; Belongs to the PINc/VapC protein family. (145 aa)    
Predicted Functional Partners:
vapB48
Possible antitoxin VapB48; Possibly the antitoxin component of a type II toxin-antitoxin (TA) system. Its cognate toxin is VapC48.
       0.863
vapB43
Possible antitoxin VapB43; Antitoxin component of a type II toxin-antitoxin (TA) system. Upon expression in M.smegmatis neutralizes the effect of cognate toxin VapC43.
   
   0.788
vapC25
Possible toxin VapC25. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB25.; Belongs to the PINc/VapC protein family.
  
     0.774
vapC31
Possible toxin VapC31. Contains PIN domain; Toxic component of a type II toxin-antitoxin (TA) system. An RNase (By similarity). Upon expression in M.smegmatis inhibits colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB31 (By similarity).
  
     0.774
glpK
Probable glycerol kinase GlpK (ATP:glycerol 3-phosphotransferase) (glycerokinase) (GK); Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family.
       0.641
relE
Toxin RelE; Toxic component of a type II toxin-antitoxin (TA) system. Has RNase activity (By similarity). Overexpression in M.tuberculosis or M.smegmatis inhibits colony formation in a bacteriostatic rather than bacteriocidal fashion. Its toxic effect is neutralized by coexpression with cognate antitoxin RelB (shown only for M.smegmatis).
 
   
 0.639
Rv3698
Conserved protein; Rv3698, (MTV025.046), len: 509 aa. Conserved protein, highly similar to Q9AK89|SC10A9.15c conserved hypothetical protein from Streptomyces coelicolor (505 aa),FASTA scores: opt: 1720, E(): 9e-103, (53.65% identity in 494 aa overlap). N-terminal end highly similar to CAC42136|SCBAC25F8.01 conserved hypothetical protein (fragment) from Streptomyces coelicolor (291 aa), FASTA scores: opt: 1078, E(): 8.7e-62, (52.6% identity in 291 aa overlap); and C-terminus highly similar to CAC44687|SCBAC17A6.42c (235 aa), FASTA scores: opt: 911,E(): 3.8e-51, (57.25% identity in 234 a [...]
       0.587
vapB5
Possible antitoxin VapB5; Probable antitoxin component of a type II toxin-antitoxin (TA) system. The cognate toxin is VapC5.
 
     0.539
Rv3699
Conserved protein; Rv3699, (MTV025.047), len: 233 aa. Conserved protein, showing similarity with hypothetical proteins e.g. Q9P3V6|SPAC1348.04 (alias Q9P3E7|SPAC750.03c or Q9P7U5|SPAC977.03) from Schizosaccharomyces pombe (Fission yeast) (145 aa), FASTA scores: opt: 188, E(): 7.5e-05,(31.65% identity in 120 aa overlap); and Q9KB70|BH2058 from Bacillus halodurans (241 aa) FASTA scores: opt: 185, E(): 0.00018, (27.8% identity in 162 aa overlap); Q9XA90|SCF43A.25c putative methyltransferase from Streptomyces coelicolor (215 aa), FASTA scores: opt: 166,E(): 0.0025, (29.95% identity in 147 [...]
  
    0.526
vapC4
Possible toxin VapC4; Toxic component of a type II toxin-antitoxin (TA) system. Probably exerts its toxic effect by binding to mRNA, inhibiting translation. Binds to, recognizes and cleaves ssRNA at ACGC and AC(A/U)GC sequences, usually between the G and C; cleavage is not very efficient, nor is cleavage required to inhibit protein synthesis. Upon expression in situ, in M.smegmatis or E.coli inhibits cell growth and colony formation; in at least E.coli also causes increased levels of cellular RNA. Its toxic effect is neutralized by coexpression with cognate antitoxin VapB4.
  
     0.523
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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