STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Rv3733cRv3733c, (MTV025.081c), len: 166 aa. Conserved hypothetical protein, highly similar to Q9FCB0|2SCG58.03 putative mutt-like protein from Streptomyces coelicolor (153 aa), FASTA scores: opt: 541, E(): 7.2e-29, (52.7% identity in 148 aa overlap); and BAB49143|MLR1881 hypothetical protein from Rhizobium loti (Mesorhizobium loti) (156 aa), FASTA scores: opt: 526, E(): 7.2e-28,(52.65% identity in 150 aa overlap). (166 aa)    
Predicted Functional Partners:
tgs2
Putative triacylglycerol synthase (diacylglycerol acyltransferase) Tgs2; Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for storage lipid synthesis (By similarity).
  
    0.906
dhmA1
Probable haloalkane dehalogenase; Catalyzes hydrolytic cleavage of carbon-halogen bonds in halogenated aliphatic compounds, leading to the formation of the corresponding primary alcohols, halide ions and protons; Belongs to the haloalkane dehalogenase family. Type 1 subfamily.
  
    0.546
Rv3735
Rv3735, (MTV025.083), len: 162 aa. Conserved hypothetical protein, highly similar to several bacterial hypothetical proteins e.g. Q9UX41|ORF-C09_016|SSO0651|AAK40956 from Sulfolobus solfataricus (163 aa), FASTA scores: opt: 627, E(): 1.2e-34, (55.9% identity in 161 aa overlap); O26795|MTH699 from Methanobacterium thermoautotrophicum (168 aa), FASTA scores: opt: 616, E(): 6.7e-34, (56.1% identity in 155 aa overlap); |Q9Y9J9|APE2289 from Aeropyrum pernix (191 aa),FASTA scores: opt: 591, E(): 3.4e-32, (54.65% identity in 161 aa overlap); etc. Contains PS00435 Peroxidases proximal heme-lig [...]
  
    0.534
ligD
Multifunctional non-homologous end joining DNA repair protein LigD; With Ku forms a non-homologous end joining (NHEJ) repair enzyme which repairs DNA double-strand breaks (DSB) with reduced fidelity. Recognizes, processes and reseals DSBs, including repairs on incompatible DSB which require 3'-resection, gap filling and ligation. Anneals the 3' overhanging strands from opposing breaks to form a gapped intermediate, which then can be extended in trans by using the termini as primers for extension of the annealed break. Binds to the recessed 5'-phosphate moiety of the downstream DNA stra [...]
 
    0.421
Rv3737
Rv3737, (MTV025.085), len: 529 aa. Probable conserved transmembrane protein, similar to others and also some hypothetical proteins e.g. AAK61331|THRE threonine export carrier from Corynebacterium glutamicum (Brevibacterium flavum) (489 aa), FASTA scores: opt: 773,E(): 1.8e-36, (37.25% identity in 424 aa overlap); Q9X8J0|SCE9.17 putative membrane protein from Streptomyces coelicolor (578 aa), FASTA scores: opt: 642, E(): 5.4e-29,(31.6% identity in 481 aa overlap) (shorter 119 aa at N-terminus); Q9CJU6|PM1895 hypothetical protein from Pasteurella multocida (262 aa), FASTA scores: opt: 23 [...]
  
    0.401
Your Current Organism:
Mycobacterium tuberculosis H37Rv
NCBI taxonomy Id: 83332
Other names: M. tuberculosis H37Rv, Mycobacterium sp. H37Rv, Mycobacterium tuberculosis str. H37Rv, Mycobacterium tuberculosis strain H37Rv
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.