node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
eccA2 | eccB2 | Rv3884c | Rv3895c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.888 |
eccA2 | eccB4 | Rv3884c | Rv3450c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.897 |
eccA2 | eccE1 | Rv3884c | Rv3882c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | 0.801 |
eccA2 | mycP1 | Rv3884c | Rv3883c | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.912 |
eccB1 | eccCa1 | Rv3869 | Rv3870 | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.997 |
eccB1 | eccD1 | Rv3869 | Rv3877 | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | ESX-1 secretion system protein EccD1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.980 |
eccB1 | eccE1 | Rv3869 | Rv3882c | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | 0.974 |
eccB1 | espB | Rv3869 | Rv3881c | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | Secreted ESX-1 substrate protein B, EspB. Conserved alanine and glycine rich protein; Required for host-cell death and may support an EsxA- independent virulence function. Secreted processed form of EspB binds to phosphatidic acid and phosphatidylserine. Inhibits IFN-gamma-induced autophagy in murine macrophages. | 0.765 |
eccB1 | espK | Rv3869 | Rv3879c | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | ESX-1 secretion-associated protein EspK. Alanine and proline rich protein; May act as a chaperone that facilitates EspB secretion through an interaction with EccCb1. | 0.896 |
eccB1 | mycP1 | Rv3869 | Rv3883c | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.842 |
eccB2 | eccA2 | Rv3895c | Rv3884c | ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | 0.888 |
eccB2 | eccB4 | Rv3895c | Rv3450c | ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.429 |
eccB2 | mycP1 | Rv3895c | Rv3883c | ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.672 |
eccB4 | eccA2 | Rv3450c | Rv3884c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-2 secretion system protein EccA2; Shows ATPase activity. Could provide energy for export of ESX-2 substrates (By similarity). | 0.897 |
eccB4 | eccB2 | Rv3450c | Rv3895c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX conserved component EccB2. ESX-2 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | 0.429 |
eccB4 | eccCa1 | Rv3450c | Rv3870 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.699 |
eccB4 | eccD1 | Rv3450c | Rv3877 | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX-1 secretion system protein EccD1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | 0.444 |
eccB4 | eccE1 | Rv3450c | Rv3882c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). Belongs to the EccE family. | 0.750 |
eccB4 | mycP1 | Rv3450c | Rv3883c | ESX conserved component EccB4. ESX-4 type VII secretion system protein. Probable membrane protein; An ATPase (By similarity). | Mycosin-1; May play a dual role in regulation of ESX-1 secretion and virulence. Acts as a protease that cleaves EspB. Essential for ESX-1 function, required for early replication in macrophages and full virulence in mice; Belongs to the peptidase S8 family. | 0.808 |
eccCa1 | eccB1 | Rv3870 | Rv3869 | ESX-1 secretion system protein EccCa1; Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10). | ESX conserved component EccB1. ESX-1 type VII secretion system protein. Possible membrane protein; An ATPase. Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT- 6) and EsxB (CFP-10) .; Belongs to the EccB family. | 0.997 |