node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ebgA | ebgC | b3076 | b3077 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | 0.998 |
ebgA | ebgR | b3076 | b3075 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Transcriptional repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. | 0.943 |
ebgA | galM | b3076 | b0756 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. | 0.927 |
ebgA | glk | b3076 | b2388 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. | 0.901 |
ebgA | lacZ | b3076 | b0344 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.925 |
ebgA | melA | b3076 | b4119 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Alpha-galactosidase, NAD(P)-binding; Alpha-galactosidase; Protein involved in carbohydrate catabolic process and NAD biosynthetic process; Belongs to the glycosyl hydrolase 4 family. | 0.938 |
ebgA | xylA | b3076 | b3565 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | 0.819 |
ebgA | ygjI | b3076 | b3078 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Putative oxidoreductase. | 0.947 |
ebgA | ygjK | b3076 | b3080 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Alpha-glucosidase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose. | 0.777 |
ebgA | yihR | b3076 | b3879 | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | Putative sulphoquinovose mutarotase; Putative aldose-1-epimerase. | 0.916 |
ebgC | ebgA | b3077 | b3076 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Evolved beta-D-galactosidase, alpha subunit; The wild-type enzyme is an ineffective lactase. Two classes of point mutations dramatically improve activity of the enzyme; Belongs to the glycosyl hydrolase 2 family. | 0.998 |
ebgC | ebgR | b3077 | b3075 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Transcriptional repressor; Repressor for beta galactosidase alpha and beta subunits (ebgA and ebgC). Binds lactose as an inducer. | 0.746 |
ebgC | galM | b3077 | b0756 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Aldose 1-epimerase; Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. | 0.900 |
ebgC | glk | b3077 | b2388 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Glucokinase; Not highly important in E.coli as glucose is transported into the cell by the PTS system already as glucose 6-phosphate. | 0.900 |
ebgC | lacZ | b3077 | b0344 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | beta-D-galactosidase; Protein involved in carbohydrate catabolic process; Belongs to the glycosyl hydrolase 2 family. | 0.904 |
ebgC | melA | b3077 | b4119 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Alpha-galactosidase, NAD(P)-binding; Alpha-galactosidase; Protein involved in carbohydrate catabolic process and NAD biosynthetic process; Belongs to the glycosyl hydrolase 4 family. | 0.900 |
ebgC | xylA | b3077 | b3565 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | D-xylose isomerase; Protein involved in carbohydrate catabolic process and glucose metabolic process; Belongs to the xylose isomerase family. | 0.800 |
ebgC | ygjI | b3077 | b3078 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Putative oxidoreductase. | 0.960 |
ebgC | ygjK | b3077 | b3080 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Alpha-glucosidase; Glucoside hydrolase that cleaves the alpha-1,3-glucosidic linkage in nigerose. Has very low activity towards maltooligosaccharides, soluble starch, nigerotriose, kojibiose and trehalose. | 0.826 |
ebgC | yihR | b3077 | b3879 | Evolved beta-D-galactosidase, beta subunit; Required for full activity of the EbgA enzyme. Exact function not known. | Putative sulphoquinovose mutarotase; Putative aldose-1-epimerase. | 0.900 |