STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yhjYAutotransporter beta-domain protein; Putative lipase; Protein involved in fatty acid oxidation. (232 aa)    
Predicted Functional Partners:
yehY
Putative ABC transporter permease; Part of an ABC transporter complex involved in low-affinity glycine betaine uptake. Probably responsible for the translocation of the substrate across the membrane.
      
 0.811
ycgB
SpoVR family stationary phase protein; To B.subtilis SpoVR.
   
  
 0.670
tag
3-methyl-adenine DNA glycosylase I, constitutive; Hydrolysis of the deoxyribose N-glycosidic bond to excise 3- methyladenine from the damaged DNA polymer formed by alkylation lesions.
  
    0.668
yahO
Periplasmic protein, function unknown, YhcN family.
   
  
 0.659
ygaU
Uncharacterized protein; Highly specific potassium binding protein that is required for normal growth in the presence of high levels of external K(+). May act as a sensor of cytoplasmic K(+) concentration. Binds a single K(+) ion, which induces a large conformational change. Can also bind the larger alkali metal ions Rb(+) and Cs(+), and NH(4)(+). May be involved in the regulation of peptidoglycan cross-linking.
   
  
 0.637
ydbH
Putative membrane-anchored protein, function unknown.
      
 0.556
ahr
Broad specificity NADPH-dependent aldehyde reductase, Zn-containing; Catalyzes the reduction of a wide range of aldehydes including aliphatic fatty aldehydes (C4-C16), into their corresponding alcohols. Has a strong preference for NADPH over NADH as the electron donor. Cannot use glyceraldehyde or a ketone as substrate. Is a relevant source of NADPH-dependent aldehyde reductase activity in E.coli. The in vivo functions of Ahr has yet to be determined.
   
  
 0.555
mcbR
Colanic acid and biofilm gene transcriptional regulator, MqsR-controlled; Important for biofilm formation. Represses expression of McbA by binding to its promoter region, which prevents colanic acid overproduction and mucoidy.
   
  
 0.553
yjdN
Metalloprotein superfamily protein.
   
    0.541
yeaG
Protein kinase, endogenous substrate unidentified; autokinase; Belongs to the PrkA family.
   
  
 0.538
Your Current Organism:
Escherichia coli K12
NCBI taxonomy Id: 511145
Other names: E. coli str. K-12 substr. MG1655, Escherichia coli MG1655, Escherichia coli str. K-12 substr. MG1655, Escherichia coli str. K12 substr. MG1655, Escherichia coli str. MG1655, Escherichia coli strain MG1655
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.