STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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entCIsochorismate hydroxymutase 2, enterochelin biosynthesis; Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate. (391 aa)    
Predicted Functional Partners:
entE
2,3-dihydroxybenzoate-AMP ligase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate excha [...]
 
  
 0.999
entB
2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor o [...]
 
 
 0.999
entA
2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596.
 
  
 0.994
entF
ATP-dependent serine activating enzyme (may be part of enterobactin synthase as component F); Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme f [...]
 
  
 0.990
fes
Enterochelin esterase; Residues 1 to 374 of 374 are 98.12 pct identical to residues 1 to 374 of 374 from Escherichia coli K-12 Strain MG1655: B0585.
 
  
 0.975
menD
2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
 0.974
fepB
Ferric enterobactin (enterochelin) binding protein; Residues 1 to 318 of 318 are 98.42 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 Strain MG1655: B0592.
 
  
 0.967
fepA
Outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D; Residues 1 to 746 of 746 are 99.19 pct identical to residues 1 to 746 of 746 from Escherichia coli K-12 Strain MG1655: B0584.
  
  
 0.955
ybdB
Orf, hypothetical protein; Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Belongs to the thioesterase PaaI family.
 
  
 0.955
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
 
 
 0.937
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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