node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cirA | entA | Z3411 | Z0738 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | 0.659 |
cirA | entB | Z3411 | Z0737 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor o [...] | 0.865 |
cirA | entC | Z3411 | Z0735 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | Isochorismate hydroxymutase 2, enterochelin biosynthesis; Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate. | 0.910 |
cirA | entD | Z3411 | Z0723 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | Enterobactin synthetase component D; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-fo [...] | 0.528 |
cirA | entE | Z3411 | Z0736 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | 2,3-dihydroxybenzoate-AMP ligase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate excha [...] | 0.632 |
cirA | entF | Z3411 | Z0727 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | ATP-dependent serine activating enzyme (may be part of enterobactin synthase as component F); Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme f [...] | 0.428 |
cirA | fepA | Z3411 | Z0724 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | Outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D; Residues 1 to 746 of 746 are 99.19 pct identical to residues 1 to 746 of 746 from Escherichia coli K-12 Strain MG1655: B0584. | 0.909 |
cirA | fepB | Z3411 | Z0734 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | Ferric enterobactin (enterochelin) binding protein; Residues 1 to 318 of 318 are 98.42 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 Strain MG1655: B0592. | 0.644 |
cirA | ybdB | Z3411 | Z0739 | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | Orf, hypothetical protein; Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Belongs to the thioesterase PaaI family. | 0.557 |
entA | cirA | Z0738 | Z3411 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | 0.659 |
entA | entB | Z0738 | Z0737 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor o [...] | 0.999 |
entA | entC | Z0738 | Z0735 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Isochorismate hydroxymutase 2, enterochelin biosynthesis; Involved in the biosynthesis of the siderophore enterobactin (macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine). Catalyzes the reversible conversion of chorismate to isochorismate. | 0.994 |
entA | entD | Z0738 | Z0723 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Enterobactin synthetase component D; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Plays an essential role in the assembly of the enterobactin by catalyzing the transfer of the 4'-phosphopantetheine (Ppant) moiety from coenzyme A to the apo- domains of both EntB (ArCP domain) and EntF (PCP domain) to yield their holo-fo [...] | 0.992 |
entA | entE | Z0738 | Z0736 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | 2,3-dihydroxybenzoate-AMP ligase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntE proccesses via a two-step adenylation-ligation reaction (bi-uni-uni-bi ping-pong mechanism). First, it catalyzes the activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via a reversible ATP-dependent pyrophosphate excha [...] | 0.999 |
entA | entF | Z0738 | Z0727 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | ATP-dependent serine activating enzyme (may be part of enterobactin synthase as component F); Activates the carboxylate group of L-serine via ATP-dependent PPi exchange reactions to the aminoacyladenylate, preparing that molecule for the final stages of enterobactin synthesis. Holo-EntF acts as the catalyst for the formation of the three amide and three ester bonds present in the cyclic (2,3-dihydroxybenzoyl)serine trimer enterobactin, using seryladenylate and acyl-holo-EntB (acylated with 2,3-dihydroxybenzoate by EntE) (By similarity); Belongs to the ATP-dependent AMP-binding enzyme f [...] | 0.998 |
entA | fepA | Z0738 | Z0724 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Outer membrane receptor for ferric enterobactin (enterochelin) and colicins B and D; Residues 1 to 746 of 746 are 99.19 pct identical to residues 1 to 746 of 746 from Escherichia coli K-12 Strain MG1655: B0584. | 0.946 |
entA | fepB | Z0738 | Z0734 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Ferric enterobactin (enterochelin) binding protein; Residues 1 to 318 of 318 are 98.42 pct identical to residues 1 to 318 of 318 from Escherichia coli K-12 Strain MG1655: B0592. | 0.925 |
entA | ybdB | Z0738 | Z0739 | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | Orf, hypothetical protein; Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules. Belongs to the thioesterase PaaI family. | 0.998 |
entB | cirA | Z0737 | Z3411 | 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor o [...] | Outer membrane receptor for iron-regulated colicin I receptor; Residues 1 to 659 of 659 are 98.79 pct identical to residues 1 to 663 of 663 from Escherichia coli K-12 Strain MG1655: B2155. | 0.865 |
entB | entA | Z0737 | Z0738 | 2,3-dihydro-2,3-dihydroxybenzoate synthetase, isochroismatase; Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3- dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. EntB is a bifunctional protein that serves as an isochorismate lyase and an aryl carrier protein (ArCP). Catalyzes the conversion of isochorismate to 2,3-dihydro-2,3-dihydroxybenzoate (2,3-diDHB), the precursor o [...] | 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase, enterochelin biosynthesis; Residues 1 to 248 of 248 are 99.19 pct identical to residues 1 to 248 of 248 from Escherichia coli K-12 Strain MG1655: B0596. | 0.999 |