STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yejLOrf, hypothetical protein; Residues 1 to 75 of 75 are 100.00 pct identical to residues 1 to 75 of 75 from Escherichia coli K-12 Strain MG1655: B2187; Belongs to the UPF0352 family. (75 aa)    
Predicted Functional Partners:
yejM
Putative sulfatase; Residues 1 to 586 of 586 are 100.00 pct identical to residues 1 to 586 of 586 from Escherichia coli K-12 Strain MG1655: B2188.
 
  
 0.937
seqA
Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.774
fadR
Negative regulator for fad regulon, and positive activator of fabA; Multifunctional regulator of fatty acid metabolism.
  
     0.773
yjgD
Orf, hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.765
yejK
Orf, hypothetical protein; Residues 1 to 335 of 335 are 99.70 pct identical to residues 1 to 335 of 335 from Escherichia coli K-12 Strain MG1655: B2186.
 
   
 0.763
yfbV
Orf, hypothetical protein; Residues 1 to 151 of 151 are 100.00 pct identical to residues 1 to 151 of 151 from Escherichia coli K-12 Strain MG1655: B2295.
  
     0.763
ccmD
Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.
  
     0.760
mutH
Methyl-directed mismatch repair; Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair; Belongs to the MutH family.
  
     0.752
tatB
Hypothetical protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.
  
     0.751
yheV
Hypothetical protein; No significant matches.
  
     0.747
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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