STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfiEndonuclease V (deoxyinosine 3'endoduclease); DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (223 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
    0.896
Z0953
Unknown protein encoded by prophage CP-933K; Residues 1 to 207 of 207 are 95.65 pct identical to residues 1 to 204 of 204 from GenPept 118 : gi|4539482|emb|CAB39991.1| (AJ237660) NinG protein [Bacteriophage 21].
      
 0.721
Z1458
Unknown protein encoded by bacteriophage BP-933W; Residues 1 to 201 of 201 are 100.00 pct identical to residues 1 to 201 of 201 from GenPept 118 : gi|4585414|gb|AAD25442.1|AF125520_37 (AF125520) hypothetical protein [Bacteriophage 933W].
      
 0.721
Z3346
Unknown protein encoded within prophage CP-933V; Residues 1 to 201 of 201 are 96.51 pct identical to residues 1 to 201 of 201 from GenPept 118 : gi|4585414|gb|AAD25442.1|AF125520_37 (AF125520) hypothetical protein [Bacteriophage 933W].
      
 0.721
Orf-30
Orf; Residues 1 to 382 of 387 are 45.27 pct identical to residues 256 to 652 of 658 from GenPept 118 : gi|2313625|gb|AAD07579.1| (AE000565) H. pylori predicted coding region HP0513 [Helicobacter pylori 26695].
      
 0.702
yjaG
Orf, hypothetical protein; Residues 1 to 196 of 196 are 99.48 pct identical to residues 1 to 196 of 196 from Escherichia coli K-12 Strain MG1655: B3999.
  
    0.691
mutM
Formamidopyrimidine DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
    
 
 0.670
yggV
Putative ribosomal protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
     
 0.644
yjaD
Orf, hypothetical protein; Residues 1 to 257 of 257 are 98.44 pct identical to residues 1 to 257 of 257 from Escherichia coli K-12 Strain MG1655: B3996.
       0.642
nfo
Endonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
      
 0.622
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
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