STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrBAspartate carbamoyltransferase, catalytic subunit; Residues 1 to 311 of 311 are 100.00 pct identical to residues 1 to 311 of 311 from Escherichia coli K-12 Strain MG1655: B4245; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)    
Predicted Functional Partners:
carA
Carbamoyl-phosphate synthetase, glutamine (small) subunit; Residues 1 to 382 of 382 are 100.00 pct identical to residues 1 to 382 of 382 from Escherichia coli K-12 Strain MG1655: B0032; Belongs to the CarA family.
 
 0.999
carB
Carbamoyl-phosphate synthase large subunit; Residues 1 to 1073 of 1073 are 99.72 pct identical to residues 1 to 1073 of 1073 from Escherichia coli K-12 Strain MG1655: B0033.
 
 0.999
pyrI
Aspartate carbamoyltransferase, regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
 0.999
pyrC
Dihydro-orotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
   
 
 0.987
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.971
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
  
 0.969
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 
 0.938
asnB
Asparagine synthetase B; Residues 1 to 554 of 554 are 99.45 pct identical to residues 1 to 554 of 554 from Escherichia coli K-12 Strain MG1655: B0674.
  
 
 0.923
pyrD
Dihydro-orotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
 
  
 0.921
ansA
Cytoplasmic L-asparaginase I; Residues 1 to 338 of 338 are 100.00 pct identical to residues 1 to 338 of 338 from Escherichia coli K-12 Strain MG1655: B1767; Belongs to the asparaginase 1 family.
  
  
  0.911
Your Current Organism:
Escherichia coli O157H7 EDL933
NCBI taxonomy Id: 155864
Other names: E. coli O157:H7 str. EDL933, Escherichia coli O157:H7 EDL933, Escherichia coli O157:H7 str. EDL933, Escherichia coli O157:H7 strain EDL933
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.