SDG50006.1 protein (Roseospirillum parvum) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

SDG50006.1

Predicted kinase, aminoglycoside phosphotransferase (APT) family. (349 aa)

Predicted Functional Partners:

SDG49965.1

0.994

SDH48294.1

0.980

SDG72331.1

0.917

SDG91339.1

0.913

SDG49843.1

0.836

SDG49932.1

0.737

SDG49892.1

0.723

SDG49807.1

0.626

SDG73097.1

0.615

SDG50042.1

0.603

Your Current Organism:

Roseospirillum parvum

NCBI taxonomy Id: 83401
Other names: DSM 12498, R. parvum, Roseospirillum parvum Glaeser and Overmann 2001, strain 930I

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDG49807.1	SDG49843.1	SAMN05421742_101403	SAMN05421742_101404	3-hydroxybutyryl-CoA dehydrogenase.	butyryl-CoA dehydrogenase.	0.862
SDG49807.1	SDG49892.1	SAMN05421742_101403	SAMN05421742_101405	3-hydroxybutyryl-CoA dehydrogenase.	DNA-binding transcriptional regulator, FadR family.	0.693
SDG49807.1	SDG49932.1	SAMN05421742_101403	SAMN05421742_101406	3-hydroxybutyryl-CoA dehydrogenase.	acetoacetyl-CoA reductase/3-oxoacyl-[acyl-carrier protein] reductase/meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase.	0.707
SDG49807.1	SDG49965.1	SAMN05421742_101403	SAMN05421742_101407	3-hydroxybutyryl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.850
SDG49807.1	SDG50006.1	SAMN05421742_101403	SAMN05421742_101408	3-hydroxybutyryl-CoA dehydrogenase.	Predicted kinase, aminoglycoside phosphotransferase (APT) family.	0.626
SDG49807.1	SDG50042.1	SAMN05421742_101403	SAMN05421742_101409	3-hydroxybutyryl-CoA dehydrogenase.	Putative NAD(P)H quinone oxidoreductase, PIG3 family.	0.529
SDG49807.1	SDG72331.1	SAMN05421742_101403	SAMN05421742_102230	3-hydroxybutyryl-CoA dehydrogenase.	Hypothetical protein.	0.736
SDG49807.1	SDG91339.1	SAMN05421742_101403	SAMN05421742_103185	3-hydroxybutyryl-CoA dehydrogenase.	Hypothetical protein.	0.645
SDG49807.1	SDH48294.1	SAMN05421742_101403	SAMN05421742_10785	3-hydroxybutyryl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.589
SDG49843.1	SDG49807.1	SAMN05421742_101404	SAMN05421742_101403	butyryl-CoA dehydrogenase.	3-hydroxybutyryl-CoA dehydrogenase.	0.862
SDG49843.1	SDG49892.1	SAMN05421742_101404	SAMN05421742_101405	butyryl-CoA dehydrogenase.	DNA-binding transcriptional regulator, FadR family.	0.747
SDG49843.1	SDG49932.1	SAMN05421742_101404	SAMN05421742_101406	butyryl-CoA dehydrogenase.	acetoacetyl-CoA reductase/3-oxoacyl-[acyl-carrier protein] reductase/meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase.	0.769
SDG49843.1	SDG49965.1	SAMN05421742_101404	SAMN05421742_101407	butyryl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.800
SDG49843.1	SDG50006.1	SAMN05421742_101404	SAMN05421742_101408	butyryl-CoA dehydrogenase.	Predicted kinase, aminoglycoside phosphotransferase (APT) family.	0.836
SDG49843.1	SDG50042.1	SAMN05421742_101404	SAMN05421742_101409	butyryl-CoA dehydrogenase.	Putative NAD(P)H quinone oxidoreductase, PIG3 family.	0.512
SDG49843.1	SDH48294.1	SAMN05421742_101404	SAMN05421742_10785	butyryl-CoA dehydrogenase.	acyl-CoA dehydrogenase.	0.565
SDG49892.1	SDG49807.1	SAMN05421742_101405	SAMN05421742_101403	DNA-binding transcriptional regulator, FadR family.	3-hydroxybutyryl-CoA dehydrogenase.	0.693
SDG49892.1	SDG49843.1	SAMN05421742_101405	SAMN05421742_101404	DNA-binding transcriptional regulator, FadR family.	butyryl-CoA dehydrogenase.	0.747
SDG49892.1	SDG49932.1	SAMN05421742_101405	SAMN05421742_101406	DNA-binding transcriptional regulator, FadR family.	acetoacetyl-CoA reductase/3-oxoacyl-[acyl-carrier protein] reductase/meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase.	0.834
SDG49892.1	SDG49965.1	SAMN05421742_101405	SAMN05421742_101407	DNA-binding transcriptional regulator, FadR family.	acyl-CoA dehydrogenase.	0.778

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

96

PPI enrichment p-value:

0.692

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

4 of 44

1.68

1.39

0.0010

GO:0006631

Fatty acid metabolic process

5 of 86

1.49

1.34

0.00057

GO:0044249

Cellular biosynthetic process

8 of 908

0.67

0.45

0.0120

GO:1901576

Organic substance biosynthetic process

8 of 950

0.65

0.44

0.0120

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 19

2.05

2.11

5.52e-05

GO:0004314

[Acyl-carrier-protein] S-malonyltransferase activity

2 of 2

2.72

1.14

0.0085

GO:0031177

Phosphopantetheine binding

2 of 5

2.32

1.07

0.0104

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 14

1.88

0.76

0.0352

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:451

Phosphopantetheine, and Condensation domain

8 of 21

2.3

6.37

9.28e-15

CL:454

Phosphopantetheine, and Siderophore metabolic process

7 of 14

2.42

6.17

1.56e-13

CL:456

Phosphopantetheine attachment site

6 of 7

2.65

6.03

1.88e-12

CL:434

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme

11 of 99

1.77

4.72

8.59e-17

CL:435

Mixed, incl. AMP-binding enzyme, and Alpha/beta hydrolase fold-1

9 of 68

1.84

4.5

1.07e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01053

Biosynthesis of siderophore group nonribosomal peptides

2 of 7

2.18

0.96

0.0160

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

6 of 18

2.24

4.52

2.85e-10

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

6 of 16

2.3

4.48

5.49e-10

PF00668

Condensation domain

4 of 10

2.32

2.84

2.96e-06

PF00698

Acyl transferase domain

3 of 3

2.72

2.46

2.88e-05

PF00501

AMP-binding enzyme

4 of 26

1.91

2.08

3.99e-05

PF13193

AMP-binding enzyme C-terminal domain

3 of 16

1.99

1.56

0.00083

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

6 of 18

2.24

4.14

2.50e-09

IPR009081

Phosphopantetheine binding ACP domain

6 of 18

2.24

4.14

2.50e-09

IPR020806

Polyketide synthase, phosphopantetheine-binding domain

5 of 11

2.38

3.83

2.63e-08

IPR001242

Condensation domain

4 of 10

2.32

2.79

3.74e-06

IPR006162

Phosphopantetheine attachment site

4 of 12

2.24

2.68

5.43e-06

(more ...)

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