node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDG64559.1 | SDG64586.1 | SAMN05421742_1027 | SAMN05421742_1028 | Ribonuclease, Rne/Rng family. | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.855 |
SDG64559.1 | SDG64620.1 | SAMN05421742_1027 | SAMN05421742_1029 | Ribonuclease, Rne/Rng family. | DNA repair protein RadC; Belongs to the UPF0758 family. | 0.548 |
SDG64559.1 | map | SAMN05421742_1027 | SAMN05421742_10210 | Ribonuclease, Rne/Rng family. | Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.512 |
SDG64559.1 | topA | SAMN05421742_1027 | SAMN05421742_101605 | Ribonuclease, Rne/Rng family. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.479 |
SDG64559.1 | yacG | SAMN05421742_1027 | SAMN05421742_1026 | Ribonuclease, Rne/Rng family. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.800 |
SDG64586.1 | SDG64559.1 | SAMN05421742_1028 | SAMN05421742_1027 | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Ribonuclease, Rne/Rng family. | 0.855 |
SDG64586.1 | SDG64620.1 | SAMN05421742_1028 | SAMN05421742_1029 | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | DNA repair protein RadC; Belongs to the UPF0758 family. | 0.910 |
SDG64586.1 | map | SAMN05421742_1028 | SAMN05421742_10210 | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.491 |
SDG64586.1 | yacG | SAMN05421742_1028 | SAMN05421742_1026 | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.815 |
SDG64620.1 | SDG64559.1 | SAMN05421742_1029 | SAMN05421742_1027 | DNA repair protein RadC; Belongs to the UPF0758 family. | Ribonuclease, Rne/Rng family. | 0.548 |
SDG64620.1 | SDG64586.1 | SAMN05421742_1029 | SAMN05421742_1028 | DNA repair protein RadC; Belongs to the UPF0758 family. | Septum formation protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.910 |
SDG64620.1 | SDG64793.1 | SAMN05421742_1029 | SAMN05421742_10214 | DNA repair protein RadC; Belongs to the UPF0758 family. | Hypothetical protein. | 0.402 |
SDG64620.1 | map | SAMN05421742_1029 | SAMN05421742_10210 | DNA repair protein RadC; Belongs to the UPF0758 family. | Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.794 |
SDG64620.1 | topA | SAMN05421742_1029 | SAMN05421742_101605 | DNA repair protein RadC; Belongs to the UPF0758 family. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.477 |
SDG64620.1 | yacG | SAMN05421742_1029 | SAMN05421742_1026 | DNA repair protein RadC; Belongs to the UPF0758 family. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.507 |
SDG64793.1 | SDG64620.1 | SAMN05421742_10214 | SAMN05421742_1029 | Hypothetical protein. | DNA repair protein RadC; Belongs to the UPF0758 family. | 0.402 |
SDG64793.1 | map | SAMN05421742_10214 | SAMN05421742_10210 | Hypothetical protein. | Methionyl aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. | 0.414 |
SDG64793.1 | yacG | SAMN05421742_10214 | SAMN05421742_1026 | Hypothetical protein. | Hypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. | 0.407 |
gyrA | gyrB | SAMN05421742_101328 | SAMN05421742_104230 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.996 |
gyrA | parE | SAMN05421742_101328 | SAMN05421742_107170 | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Topoisomerase-4 subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. | 0.996 |