SDH74365.1 protein (Roseospirillum parvum) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SDH74365.1

Hypothetical protein. (308 aa)

Predicted Functional Partners:

SDH74462.1

0.743

SDH74514.1

0.740

SDH74552.1

0.739

SDH74423.1

0.737

SDH74332.1

0.625

SDH74255.1

0.441

SDH74029.1

0.438

SDH74071.1

0.438

SDH74104.1

0.438

SDH74137.1

0.438

Your Current Organism:

Roseospirillum parvum

NCBI taxonomy Id: 83401
Other names: DSM 12498, R. parvum, Roseospirillum parvum Glaeser and Overmann 2001, strain 930I

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SDH74029.1	SDH74071.1	SAMN05421742_11158	SAMN05421742_11159	F5/8 type C domain-containing protein.	Hypothetical protein.	0.773
SDH74029.1	SDH74104.1	SAMN05421742_11158	SAMN05421742_11160	F5/8 type C domain-containing protein.	Putative phage tail protein.	0.773
SDH74029.1	SDH74137.1	SAMN05421742_11158	SAMN05421742_11161	F5/8 type C domain-containing protein.	NlpC/P60 family protein.	0.773
SDH74029.1	SDH74255.1	SAMN05421742_11158	SAMN05421742_11164	F5/8 type C domain-containing protein.	Phage tail tape measure protein, lambda family.	0.773
SDH74029.1	SDH74332.1	SAMN05421742_11158	SAMN05421742_11166	F5/8 type C domain-containing protein.	Hypothetical protein.	0.529
SDH74029.1	SDH74365.1	SAMN05421742_11158	SAMN05421742_11167	F5/8 type C domain-containing protein.	Hypothetical protein.	0.438
SDH74029.1	SDH74423.1	SAMN05421742_11158	SAMN05421742_11168	F5/8 type C domain-containing protein.	Hypothetical protein.	0.420
SDH74029.1	SDH74462.1	SAMN05421742_11158	SAMN05421742_11169	F5/8 type C domain-containing protein.	Hypothetical protein.	0.408
SDH74029.1	SDH74514.1	SAMN05421742_11158	SAMN05421742_11170	F5/8 type C domain-containing protein.	Hypothetical protein.	0.408
SDH74029.1	SDH74552.1	SAMN05421742_11158	SAMN05421742_11171	F5/8 type C domain-containing protein.	Hypothetical protein.	0.408
SDH74071.1	SDH74029.1	SAMN05421742_11159	SAMN05421742_11158	Hypothetical protein.	F5/8 type C domain-containing protein.	0.773
SDH74071.1	SDH74104.1	SAMN05421742_11159	SAMN05421742_11160	Hypothetical protein.	Putative phage tail protein.	0.773
SDH74071.1	SDH74137.1	SAMN05421742_11159	SAMN05421742_11161	Hypothetical protein.	NlpC/P60 family protein.	0.773
SDH74071.1	SDH74255.1	SAMN05421742_11159	SAMN05421742_11164	Hypothetical protein.	Phage tail tape measure protein, lambda family.	0.773
SDH74071.1	SDH74332.1	SAMN05421742_11159	SAMN05421742_11166	Hypothetical protein.	Hypothetical protein.	0.529
SDH74071.1	SDH74365.1	SAMN05421742_11159	SAMN05421742_11167	Hypothetical protein.	Hypothetical protein.	0.438
SDH74071.1	SDH74423.1	SAMN05421742_11159	SAMN05421742_11168	Hypothetical protein.	Hypothetical protein.	0.420
SDH74071.1	SDH74462.1	SAMN05421742_11159	SAMN05421742_11169	Hypothetical protein.	Hypothetical protein.	0.408
SDH74071.1	SDH74514.1	SAMN05421742_11159	SAMN05421742_11170	Hypothetical protein.	Hypothetical protein.	0.408
SDH74071.1	SDH74552.1	SAMN05421742_11159	SAMN05421742_11171	Hypothetical protein.	Hypothetical protein.	0.408

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

13

PPI enrichment p-value:

3.33e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006090

Pyruvate metabolic process

5 of 26

1.78

2.08

2.13e-05

GO:0045454

Cell redox homeostasis

3 of 9

2.02

1.57

0.00084

GO:0006086

acetyl-CoA biosynthetic process from pyruvate

2 of 2

2.5

1.37

0.0030

GO:0006096

Glycolytic process

3 of 18

1.72

1.22

0.0030

GO:0009150

Purine ribonucleotide metabolic process

5 of 79

1.3

1.15

0.00076

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016624

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor

5 of 7

2.35

3.66

5.65e-08

GO:0004739

Pyruvate dehydrogenase (acetyl-transferring) activity

4 of 6

2.32

2.79

3.70e-06

GO:0016417

S-acyltransferase activity

2 of 4

2.2

0.99

0.0147

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.41

0.77

0.0204

GO:0016491

Oxidoreductase activity

8 of 380

0.82

0.71

0.00036

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1404

Pyruvate dehydrogenase activity, and e3 binding domain

9 of 13

2.34

7.17

1.15e-16

CL:1406

Pyruvate dehydrogenase activity, and Peptidyl-lysine modification

5 of 5

2.5

4.42

2.31e-09

CL:1367

Mixed, incl. Citrate cycle (TCA cycle), and Oxidoreduction-driven active transmembrane transporter activity

10 of 68

1.66

3.81

5.55e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mvd00020

Citrate cycle (TCA cycle)

7 of 33

1.82

3.53

6.31e-10

mvd00620

Pyruvate metabolism

6 of 54

1.54

2.23

3.78e-07

mvd00010

Glycolysis / Gluconeogenesis

6 of 56

1.53

2.2

3.78e-07

mvd01200

Carbon metabolism

8 of 123

1.31

1.9

3.18e-08

mvd01120

Microbial metabolism in diverse environments

9 of 342

0.92

0.99

1.17e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0670

Pyruvate

5 of 17

1.97

2.85

5.77e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00676

Dehydrogenase E1 component

3 of 3

2.5

1.96

0.00023

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 3

2.32

0.9

0.0220

PF02780

Transketolase, C-terminal domain

2 of 4

2.2

0.89

0.0220

PF00198

2-oxoacid dehydrogenases acyltransferase (catalytic domain)

2 of 4

2.2

0.89

0.0220

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 5

2.1

0.89

0.0220

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 14

2.05

2.76

1.62e-06

IPR001017

Dehydrogenase, E1 component

3 of 3

2.5

1.9

0.00030

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.37

1.84

0.00035

IPR005475

Transketolase-like, pyrimidine-binding domain

3 of 6

2.2

1.67

0.00063

IPR023753

FAD/NAD(P)-binding domain

3 of 12

1.89

1.29

0.0027

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00861

Transketolase, pyrimidine binding domain

3 of 6

2.2

1.92

0.00020

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