STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)    
Predicted Functional Partners:
Lrp5.L
Uncharacterized protein.
    
 0.999
A0A1L8GQT6
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
    
 0.994
xfz8
Frizzled-8; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.977
Sfrp1.L
Uncharacterized protein.
    
 0.968
ctnnb1
Beta-catenin protein.
    
 0.967
fzd1
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.956
sfrp1
Uncharacterized protein.
    
 0.951
fzd7
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.942
Fzd4.S
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.942
fzd10
Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.942
Your Current Organism:
Xenopus laevis
NCBI taxonomy Id: 8355
Other names: African clawed frog, Bufo laevis, X. laevis, clawed frog, common platanna, platanna
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.