node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PLOD2 | camkmt | ENSXETP00000023809 | ENSXETP00000040681 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | GRB2 associated binding protein 2. | 0.900 |
PLOD2 | kmt5a | ENSXETP00000023809 | ENSXETP00000004789 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.660 |
PLOD2 | setd7 | ENSXETP00000023809 | ENSXETP00000037259 | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. | 0.675 |
ash2l | dpy30 | ENSXETP00000052160 | ENSXETP00000003560 | RAB3C, member RAS oncogene family. | General transcription factor IIIC subunit 6. | 0.996 |
ash2l | h2az1 | ENSXETP00000052160 | ENSXETP00000018677 | RAB3C, member RAS oncogene family. | Histone H2A.Z-like; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation (By similarity). | 0.402 |
ash2l | kmt5a | ENSXETP00000052160 | ENSXETP00000004789 | RAB3C, member RAS oncogene family. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.531 |
ash2l | rbbp5 | ENSXETP00000052160 | ENSXETP00000031002 | RAB3C, member RAS oncogene family. | ALG2, alpha-1,3/1,6-mannosyltransferase. | 0.996 |
ash2l | setd7 | ENSXETP00000052160 | ENSXETP00000037259 | RAB3C, member RAS oncogene family. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. | 0.504 |
camkmt | PLOD2 | ENSXETP00000040681 | ENSXETP00000023809 | GRB2 associated binding protein 2. | Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. | 0.900 |
camkmt | kmt5a | ENSXETP00000040681 | ENSXETP00000004789 | GRB2 associated binding protein 2. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.711 |
camkmt | setd7 | ENSXETP00000040681 | ENSXETP00000037259 | GRB2 associated binding protein 2. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. | 0.713 |
commd4 | h2az1 | ENSXETP00000001368 | ENSXETP00000018677 | COMM domain-containing protein. | Histone H2A.Z-like; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation (By similarity). | 0.499 |
commd4 | kmt5a | ENSXETP00000001368 | ENSXETP00000004789 | COMM domain-containing protein. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.750 |
dpy30 | ash2l | ENSXETP00000003560 | ENSXETP00000052160 | General transcription factor IIIC subunit 6. | RAB3C, member RAS oncogene family. | 0.996 |
dpy30 | h2az1 | ENSXETP00000003560 | ENSXETP00000018677 | General transcription factor IIIC subunit 6. | Histone H2A.Z-like; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be required at gastrulation for correct mesoderm formation (By similarity). | 0.659 |
dpy30 | kmt5a | ENSXETP00000003560 | ENSXETP00000004789 | General transcription factor IIIC subunit 6. | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.633 |
dpy30 | rbbp5 | ENSXETP00000003560 | ENSXETP00000031002 | General transcription factor IIIC subunit 6. | ALG2, alpha-1,3/1,6-mannosyltransferase. | 0.998 |
dpy30 | setd7 | ENSXETP00000003560 | ENSXETP00000037259 | General transcription factor IIIC subunit 6. | Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. Has also methyltransferase activity toward non-histone proteins. | 0.504 |
dtl | kmt5a | ENSXETP00000028254 | ENSXETP00000004789 | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | N-lysine methyltransferase KMT5A; Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper [...] | 0.600 |
dtl | pcna | ENSXETP00000028254 | ENSXETP00000010344 | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.912 |