node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
NOD1 | atg16l1 | ENSXETP00000004054 | ENSXETP00000031538 | Nucleotide binding oligomerization domain containing 1. | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | 0.972 |
atg12 | atg16l1 | ENSXETP00000031722 | ENSXETP00000031538 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | 0.996 |
atg12 | atg16l2 | ENSXETP00000031722 | ENSXETP00000021851 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Pyruvate dehydrogenase E1 alpha 1 subunit. | 0.990 |
atg12 | atg3 | ENSXETP00000031722 | ENSXETP00000023939 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | 0.999 |
atg12 | atg5 | ENSXETP00000031722 | ENSXETP00000034480 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.999 |
atg12 | gabarapl1 | ENSXETP00000031722 | ENSXETP00000031780 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Gamma-aminobutyric acid receptor-associated protein-like 1; Involved in autophagy; Belongs to the ATG8 family. | 0.969 |
atg12 | gabarapl2 | ENSXETP00000031722 | ENSXETP00000043383 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | Olfactory receptor family 3 subfamily A member 1. | 0.981 |
atg12 | rab33b | ENSXETP00000031722 | ENSXETP00000037237 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | RAB33B, member RAS oncogene family. | 0.537 |
atg12 | rb1cc1 | ENSXETP00000031722 | ENSXETP00000013389 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | 45 kDa calcium-binding protein. | 0.798 |
atg12 | wipi2 | ENSXETP00000031722 | ENSXETP00000027524 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | 2-hydroxyacyl-CoA lyase 1. | 0.888 |
atg16l1 | NOD1 | ENSXETP00000031538 | ENSXETP00000004054 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Nucleotide binding oligomerization domain containing 1. | 0.972 |
atg16l1 | atg12 | ENSXETP00000031538 | ENSXETP00000031722 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. | 0.996 |
atg16l1 | atg16l2 | ENSXETP00000031538 | ENSXETP00000021851 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Pyruvate dehydrogenase E1 alpha 1 subunit. | 0.918 |
atg16l1 | atg3 | ENSXETP00000031538 | ENSXETP00000023939 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Ubiquitin-like-conjugating enzyme ATG3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of atg8-like proteins (gabarap, gabarapl1, gabarapl2 or map1lc3a). The atg12-atg5 conjugate plays a role of an E3 and promotes the transfer of atg8-like proteins from atg3 to phosphatidylethanolamine (PE). This step is required for the membrane association of atg8-like proteins. The formation of the atg8- phosphatidylethanolamine conju [...] | 0.993 |
atg16l1 | atg5 | ENSXETP00000031538 | ENSXETP00000034480 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Autophagy protein 5; Involved in autophagic vesicle formation. | 0.999 |
atg16l1 | gabarapl1 | ENSXETP00000031538 | ENSXETP00000031780 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Gamma-aminobutyric acid receptor-associated protein-like 1; Involved in autophagy; Belongs to the ATG8 family. | 0.941 |
atg16l1 | gabarapl2 | ENSXETP00000031538 | ENSXETP00000043383 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | Olfactory receptor family 3 subfamily A member 1. | 0.958 |
atg16l1 | rab33b | ENSXETP00000031538 | ENSXETP00000037237 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | RAB33B, member RAS oncogene family. | 0.996 |
atg16l1 | rb1cc1 | ENSXETP00000031538 | ENSXETP00000013389 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | 45 kDa calcium-binding protein. | 0.990 |
atg16l1 | wipi2 | ENSXETP00000031538 | ENSXETP00000027524 | Autophagy-related protein 16; Plays an essential role in autophagy: interacts with ATG12- ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane; Belongs to the WD repeat ATG16 family. | 2-hydroxyacyl-CoA lyase 1. | 0.995 |