STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2534 aa)    
Predicted Functional Partners:
rptor
WD_REPEATS_REGION domain-containing protein.
   
 0.999
rictor
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1.
   
 0.999
mlst8
Target of rapamycin complex subunit lst8.
    
 0.999
tti1
Uroporphyrinogen decarboxylase.
   
 0.998
rraga
Leucyl-tRNA synthetase 2.
    
 0.997
telo2
Telomere length regulation protein TEL2 homolog; Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. Promotes assembly, stabilizes and maintains the activity of TORC complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. May be involved in telomere length regulation (By similarity).
    
 0.996
akt1s1
AKT1 substrate 1 (Proline-rich).
    
 0.996
mapkap1
Target of rapamycin complex 2 subunit MAPKAP1; Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity); Belongs to the SIN1 family.
    
 
 0.996
ulk1
Twinkle mtDNA helicase.
    
 0.989
sgk1
Serine/threonine-protein kinase Sgk1; Protein kinase that may play an important role in cellular stress response (By similarity). Plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
    
 0.989
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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