STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thsd7b-2Thrombospondin type 1 domain-containing 7B. (1982 aa)    
Predicted Functional Partners:
phb2
Prohibitin-2; Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity); Belongs to the prohibitin family.
    
 
 0.741
ccdc167
Coiled-coil domain-containing protein 167.
      
 0.592
LRRTM4
Leucine rich repeat transmembrane neuronal 4.
      
 0.578
chmp7
Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family.
      
 0.568
drg2
Distal membrane arm assembly complex 2 like.
      
 0.550
orc5
AAA_16 domain-containing protein.
      
 0.534
psip1
Zinc finger protein 711.
      
 0.463
dcbld2
Sodium-dependent phosphate transporter 1.
      
 0.463
eapp
MGC79822 protein.
      
 0.452
pkia
cAMP-dependent protein kinase inhibitor; Belongs to the PKI family.
      
 0.439
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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