node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADI1 | add3 | ENSXETP00000018742 | ENSXETP00000014363 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | ATR serine/threonine kinase. | 0.650 |
ADI1 | enoph1 | ENSXETP00000018742 | ENSXETP00000028453 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). | 0.997 |
ADI1 | gapdh | ENSXETP00000018742 | ENSXETP00000036173 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.571 |
ADI1 | mri1 | ENSXETP00000018742 | ENSXETP00000021859 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.891 |
ADI1 | mtap | ENSXETP00000018742 | ENSXETP00000015654 | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.582 |
XYLB | add3 | ENSXETP00000014629 | ENSXETP00000014363 | Xylulokinase. | ATR serine/threonine kinase. | 0.794 |
XYLB | gapdh | ENSXETP00000014629 | ENSXETP00000036173 | Xylulokinase. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.746 |
XYLB | tpi1 | ENSXETP00000014629 | ENSXETP00000017944 | Xylulokinase. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.761 |
add3 | ADI1 | ENSXETP00000014363 | ENSXETP00000018742 | ATR serine/threonine kinase. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. | 0.650 |
add3 | XYLB | ENSXETP00000014363 | ENSXETP00000014629 | ATR serine/threonine kinase. | Xylulokinase. | 0.794 |
add3 | aldh18a1 | ENSXETP00000014363 | ENSXETP00000012107 | ATR serine/threonine kinase. | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.685 |
add3 | dmtn | ENSXETP00000014363 | ENSXETP00000028948 | ATR serine/threonine kinase. | HP domain-containing protein. | 0.734 |
add3 | enoph1 | ENSXETP00000014363 | ENSXETP00000028453 | ATR serine/threonine kinase. | Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). | 0.705 |
add3 | epb41 | ENSXETP00000014363 | ENSXETP00000054489 | ATR serine/threonine kinase. | Membrane associated guanylate kinase, WW and PDZ domain containing 2. | 0.729 |
add3 | gapdh | ENSXETP00000014363 | ENSXETP00000036173 | ATR serine/threonine kinase. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.676 |
add3 | mri1 | ENSXETP00000014363 | ENSXETP00000021859 | ATR serine/threonine kinase. | Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.772 |
add3 | mtap | ENSXETP00000014363 | ENSXETP00000015654 | ATR serine/threonine kinase. | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. | 0.607 |
add3 | tpi1 | ENSXETP00000014363 | ENSXETP00000017944 | ATR serine/threonine kinase. | Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. | 0.722 |
aldh18a1 | add3 | ENSXETP00000012107 | ENSXETP00000014363 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | ATR serine/threonine kinase. | 0.685 |
aldh18a1 | gapdh | ENSXETP00000012107 | ENSXETP00000036173 | Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Glyceraldehyde-3-phosphate dehydrogenase. | 0.829 |