STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4102 aa)    
Predicted Functional Partners:
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.982
lig4
DNA ligase.
   
 
 0.971
XRCC5
X-ray repair cross complementing 5.
   
 
 0.971
xrcc6
Ku domain-containing protein.
    
 
 0.969
DCLRE1C
DNA cross-link repair 1C.
    
 
 0.959
rptor
WD_REPEATS_REGION domain-containing protein.
   
 
 0.843
rictor
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1.
   
 
 0.836
mlst8
Target of rapamycin complex subunit lst8.
    
 
 0.831
mapkap1
Target of rapamycin complex 2 subunit MAPKAP1; Essential component of the TORC2 complex, which plays a critical role in akt1 'Ser-473' phosphorylation, and may modulate the phosphorylation of pkca and regulate actin cytoskeleton organization. May interact with a MAP kinase. May act on Ras-regulated pathways (By similarity); Belongs to the SIN1 family.
    
 
 0.830
rraga
Leucyl-tRNA synthetase 2.
    
 
 0.810
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.