STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cdkn1aUncharacterized protein. (143 aa)    
Predicted Functional Partners:
ccne1
Cyclin E1; Belongs to the cyclin family.
   
 0.980
skp2
F-box domain-containing protein.
    
 0.980
ccne2
Death-associated protein kinase 2; Belongs to the cyclin family.
   
 0.977
ccna2
Cyclin A2; Belongs to the cyclin family.
    
 0.974
tigar
Fructose-2,6-bisphosphatase TIGAR; Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6- bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. May pla [...]
   
 0.965
ccna1
DEP domain containing 1B; Belongs to the cyclin family.
    
 0.962
cul1
Complexin 1; Belongs to the cullin family.
    
 0.959
cdk6
Epidermal growth factor receptor pathway substrate 15; Belongs to the protein kinase superfamily.
   
 0.956
skp1
S-phase kinase-associated protein 1A (P19A); Belongs to the SKP1 family.
    
 0.955
ccndx
Novel cyclin; Belongs to the cyclin family.
   
 0.949
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.