node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGFR | erbb2 | ENSXETP00000006905 | ENSXETP00000045564 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.903 |
EGFR | pdgfra | ENSXETP00000006905 | ENSXETP00000032900 | Receptor protein-tyrosine kinase. | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | 0.925 |
EGFR | top1mt | ENSXETP00000006905 | ENSXETP00000030700 | Receptor protein-tyrosine kinase. | Phosphoinositide phospholipase C. | 0.938 |
ERBB3 | erbb2 | ENSXETP00000053071 | ENSXETP00000045564 | Erb-b2 receptor tyrosine kinase 3. | Receptor protein-tyrosine kinase. | 0.819 |
ERBB3 | top1mt | ENSXETP00000053071 | ENSXETP00000030700 | Erb-b2 receptor tyrosine kinase 3. | Phosphoinositide phospholipase C. | 0.938 |
ERBB4 | erbb2 | ENSXETP00000046276 | ENSXETP00000045564 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.803 |
ERBB4 | top1mt | ENSXETP00000046276 | ENSXETP00000030700 | Receptor protein-tyrosine kinase. | Phosphoinositide phospholipase C. | 0.938 |
erbb2 | EGFR | ENSXETP00000045564 | ENSXETP00000006905 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.903 |
erbb2 | ERBB3 | ENSXETP00000045564 | ENSXETP00000053071 | Receptor protein-tyrosine kinase. | Erb-b2 receptor tyrosine kinase 3. | 0.819 |
erbb2 | ERBB4 | ENSXETP00000045564 | ENSXETP00000046276 | Receptor protein-tyrosine kinase. | Receptor protein-tyrosine kinase. | 0.803 |
erbb2 | top1mt | ENSXETP00000045564 | ENSXETP00000030700 | Receptor protein-tyrosine kinase. | Phosphoinositide phospholipase C. | 0.938 |
inpp5a.1 | top1mt | ENSXETP00000040854 | ENSXETP00000030700 | Inositol polyphosphate-5-phosphatase, 40kDa. | Phosphoinositide phospholipase C. | 0.913 |
itpr3 | prkcg | ENSXETP00000051746 | ENSXETP00000024388 | Inositol (1,4,5) trisphosphate receptor type 3. | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | 0.908 |
itpr3 | top1mt | ENSXETP00000051746 | ENSXETP00000030700 | Inositol (1,4,5) trisphosphate receptor type 3. | Phosphoinositide phospholipase C. | 0.922 |
pdgfra | EGFR | ENSXETP00000032900 | ENSXETP00000006905 | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | Receptor protein-tyrosine kinase. | 0.925 |
pdgfra | top1mt | ENSXETP00000032900 | ENSXETP00000030700 | Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. | Phosphoinositide phospholipase C. | 0.927 |
pla2g4a | top1mt | ENSXETP00000006955 | ENSXETP00000030700 | Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response (By similarity). | Phosphoinositide phospholipase C. | 0.912 |
prkcg | itpr3 | ENSXETP00000024388 | ENSXETP00000051746 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Inositol (1,4,5) trisphosphate receptor type 3. | 0.908 |
prkcg | top1mt | ENSXETP00000024388 | ENSXETP00000030700 | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. | Phosphoinositide phospholipase C. | 0.907 |
pten | top1mt | ENSXETP00000010146 | ENSXETP00000030700 | Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. | Phosphoinositide phospholipase C. | 0.910 |