STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aplnrApelin receptor; Receptor for apelin receptor early endogenous ligand (apela) and apelin (apln) hormones coupled to G proteins that inhibit adenylate cyclase activity. Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively. Promotes angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis [...] (363 aa)    
Predicted Functional Partners:
apln
LOC100135238 protein.
   
 
 0.985
gnb1
Guanine nucleotide binding protein (G protein), beta polypeptide 2.
    
  0.955
gnb4
LOC549706 protein.
    
  0.955
gnb3
Zinc finger, BED-type-containing 8.
    
  0.954
gnb5
TATA-box binding protein associated factor 13.
    
  0.946
gnai3
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.
    
 0.937
gnai1
Uncharacterized protein.
    
 0.937
apela
Endoplasmic reticulum-Golgi intermediate compartment protein 3.
    
 
 0.931
gna13
LOC100145489 protein.
    
 0.930
gnaq
Guanine nucleotide binding protein (G protein), q polypeptide.
    
 0.913
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.