node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DOT1L | SMYD2 | ENSXETP00000035911 | ENSXETP00000008419 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | SET and MYND domain containing 2. | 0.439 |
DOT1L | camkmt | ENSXETP00000035911 | ENSXETP00000040681 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | GRB2 associated binding protein 2. | 0.925 |
DOT1L | setd1a | ENSXETP00000035911 | ENSXETP00000032683 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Cytoskeleton-associated protein 4. | 0.686 |
DOT1L | setd1b | ENSXETP00000035911 | ENSXETP00000000486 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. | 0.686 |
DOT1L | suv39h2 | ENSXETP00000035911 | ENSXETP00000004288 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.439 |
SMYD2 | DOT1L | ENSXETP00000008419 | ENSXETP00000035911 | SET and MYND domain containing 2. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.439 |
SMYD2 | camkmt | ENSXETP00000008419 | ENSXETP00000040681 | SET and MYND domain containing 2. | GRB2 associated binding protein 2. | 0.917 |
camkmt | DOT1L | ENSXETP00000040681 | ENSXETP00000035911 | GRB2 associated binding protein 2. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.925 |
camkmt | SMYD2 | ENSXETP00000040681 | ENSXETP00000008419 | GRB2 associated binding protein 2. | SET and MYND domain containing 2. | 0.917 |
camkmt | ehmt1 | ENSXETP00000040681 | ENSXETP00000000987 | GRB2 associated binding protein 2. | ATP synthase F1 subunit gamma. | 0.912 |
camkmt | ehmt2 | ENSXETP00000040681 | ENSXETP00000040568 | GRB2 associated binding protein 2. | Solute carrier family 7 (cationic amino acid transporter, y+ system), member 2, gene 1. | 0.912 |
camkmt | prdm2 | ENSXETP00000040681 | ENSXETP00000033456 | GRB2 associated binding protein 2. | WAS protein homolog associated with actin, golgi membranes and microtubules. | 0.919 |
camkmt | setd1a | ENSXETP00000040681 | ENSXETP00000032683 | GRB2 associated binding protein 2. | Cytoskeleton-associated protein 4. | 0.911 |
camkmt | setd1b | ENSXETP00000040681 | ENSXETP00000000486 | GRB2 associated binding protein 2. | Histone-lysine N-methyltransferase SETD1B; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. | 0.911 |
camkmt | setdb1 | ENSXETP00000040681 | ENSXETP00000018549 | GRB2 associated binding protein 2. | Uncharacterized protein. | 0.918 |
camkmt | setdb2 | ENSXETP00000040681 | ENSXETP00000037585 | GRB2 associated binding protein 2. | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity); Belongs to the class V-like SAM-binding meth [...] | 0.910 |
camkmt | suv39h2 | ENSXETP00000040681 | ENSXETP00000004288 | GRB2 associated binding protein 2. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.913 |
ehmt1 | camkmt | ENSXETP00000000987 | ENSXETP00000040681 | ATP synthase F1 subunit gamma. | GRB2 associated binding protein 2. | 0.912 |
ehmt1 | setdb1 | ENSXETP00000000987 | ENSXETP00000018549 | ATP synthase F1 subunit gamma. | Uncharacterized protein. | 0.406 |
ehmt1 | suv39h2 | ENSXETP00000000987 | ENSXETP00000004288 | ATP synthase F1 subunit gamma. | Histone-lysine N-methyltransferase SUV39H2; Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric re [...] | 0.427 |