STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
skilc-SKI_SMAD_bind domain-containing protein. (643 aa)    
Predicted Functional Partners:
smad4.1
Mothers against decapentaplegic homolog.
   
 
 0.848
smad2
Mothers against decapentaplegic homolog.
   
 
 0.677
smad3
Mothers against decapentaplegic homolog.
   
 
 0.677
smad9
Mothers against decapentaplegic homolog.
   
 
 0.539
smad1
Mothers against decapentaplegic homolog.
   
 
 0.539
ints8
Large tumor suppressor kinase 2.
   
 
 0.528
SMAD7
Mothers against decapentaplegic homolog.
   
 
 0.510
rnf111
E3 ubiquitin-protein ligase arkadia; E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the smad2/smad3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as smad7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. Specifically binds polysumoylated chains via SUMO interaction motifs (SIMs) and mediates ubiquitination of sumoylated substrates (By [...]
   
 
 0.500
SKI
SKI proto-oncogene.
    
  
0.448
SMAD6
Mothers against decapentaplegic homolog.
   
 
 0.437
Your Current Organism:
Xenopus tropicalis
NCBI taxonomy Id: 8364
Other names: Silurana tropicalis, X. tropicalis, Xenopus (Silurana) tropicalis, Xenopus laevis tropicalis, tropical clawed frog, western clawed frog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.