node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCB7 | FECH | ENSXETP00000045575 | ENSXETP00000036862 | ATP binding cassette subfamily B member 7. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.694 |
ABCB7 | FXN | ENSXETP00000045575 | ENSXETP00000053217 | ATP binding cassette subfamily B member 7. | Frataxin. | 0.746 |
ABCB7 | abce1 | ENSXETP00000045575 | ENSXETP00000038487 | ATP binding cassette subfamily B member 7. | ATP-binding cassette, sub-family E (OABP), member 1. | 0.727 |
ABCB7 | ciapin1 | ENSXETP00000045575 | ENSXETP00000010689 | ATP binding cassette subfamily B member 7. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.745 |
ABCB7 | isca1 | ENSXETP00000045575 | ENSXETP00000048397 | ATP binding cassette subfamily B member 7. | Endoplasmic reticulum-golgi intermediate compartment 1. | 0.745 |
ABCB7 | iscu | ENSXETP00000045575 | ENSXETP00000021749 | ATP binding cassette subfamily B member 7. | NifU-like N-terminal domain containing; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.737 |
ABCB7 | micu1 | ENSXETP00000045575 | ENSXETP00000015980 | ATP binding cassette subfamily B member 7. | Calcium uptake protein 1, mitochondrial; Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains. micu1 and micu2 form a disulfide-linked heterodimer that stimulates and inhibits mcu activity, depending on the concentration of calcium. Micu1 acts both as an activator or inhibitor of mitochondrial calcium uptake. Acts as a gatekeeper of mcu at low concentration of calcium, preventing channel opening. Enhances mcu opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm. | 0.800 |
ABCB7 | ndor1 | ENSXETP00000045575 | ENSXETP00000011195 | ATP binding cassette subfamily B member 7. | NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.730 |
ABCB7 | nfs1 | ENSXETP00000045575 | ENSXETP00000026609 | ATP binding cassette subfamily B member 7. | Neurochondrin. | 0.746 |
ABCB7 | sdc1 | ENSXETP00000045575 | ENSXETP00000005736 | ATP binding cassette subfamily B member 7. | Syndecan 1. | 0.695 |
FECH | ABCB7 | ENSXETP00000036862 | ENSXETP00000045575 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | ATP binding cassette subfamily B member 7. | 0.694 |
FECH | FXN | ENSXETP00000036862 | ENSXETP00000053217 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Frataxin. | 0.985 |
FECH | abce1 | ENSXETP00000036862 | ENSXETP00000038487 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | ATP-binding cassette, sub-family E (OABP), member 1. | 0.554 |
FECH | ciapin1 | ENSXETP00000036862 | ENSXETP00000010689 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.483 |
FECH | isca1 | ENSXETP00000036862 | ENSXETP00000048397 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Endoplasmic reticulum-golgi intermediate compartment 1. | 0.681 |
FECH | iscu | ENSXETP00000036862 | ENSXETP00000021749 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | NifU-like N-terminal domain containing; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. | 0.758 |
FECH | nfs1 | ENSXETP00000036862 | ENSXETP00000026609 | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | Neurochondrin. | 0.632 |
FXN | ABCB7 | ENSXETP00000053217 | ENSXETP00000045575 | Frataxin. | ATP binding cassette subfamily B member 7. | 0.746 |
FXN | FECH | ENSXETP00000053217 | ENSXETP00000036862 | Frataxin. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. | 0.985 |
FXN | ciapin1 | ENSXETP00000053217 | ENSXETP00000010689 | Frataxin. | Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] | 0.602 |